Chem: the research group of Professor Shi Zhuangzhi of Nanjing University has made progress in copper catalyzed asymmetric defluorination and boration

Difluoroenyl is a common segment in drug design, which shows similar spatial and electronic properties to the corresponding carbonyl substituents Therefore, it is often used as an isoelectron of carbonyl, such as difluoroenylated biologically active ketones and esters, which have been prepared to improve the biological activity, target specificity and metabolic stability of drugs It is of great significance to study how to construct and transform amphiphilic olefins efficiently and rapidly Professor Shi Zhuangzhi, National Key Laboratory of coordination chemistry, School of chemistry and chemical engineering, Nanjing University, has made a series of progress in this field Based on the research group's previous work in copper catalyzed stereospecific defluorination and hydrogenation (angel Chem Int ed 2017, 56, 13342), and asymmetric defluorination (j.am Chem SOC 2018, 140, 9061) in recent years, the team has also realized the copper catalyzed asymmetric defluorination and boronization of trifluoromethylolefins, and has synthesized a series of borate containing Bifluorene hydrocarbons with high stereoselectivity Because the constructed chiral C-B bond can be easily converted into corresponding C-C bond, C-O bond and other carbon heterobonds, based on the diversity of boron chemistry, various carbonyl and other electronic bodies can be synthesized rapidly and efficiently for biological and pharmaceutical synthesis This achievement was published on Chem under the title of "copper catalyzed informal eluoboration of 1 - (trifluoromethyl) alkenes" (DOI: 10.1016 / j.chempr 2018.07.003) Gao Pan, a 2016 doctoral student, is the first author of this paper The above research work has been funded by the "youth thousand" program of the Central Organization Department, the National Natural Science Foundation, the "entrepreneurship and Innovation Program" of Jiangsu Province, and the State Key Laboratory of coordination chemistry Copper catalyzed asymmetric defluoroberonization of trifluoromethylolefins (source: Chem)