Chemistry tips: it's time to collect this updated MNR chemical displacement table

In 1997, Gottlieb, kotlyar and nudelman, from the University of Baylan, Israel, published an article entitled NMR chemical shifts of common laboratory solutions as trace improvements (J org Chem 1997, 62, 7512) on J org Chem In this paper, seven common deuterium reagents (CdCl 3, (CD 3) 2 Co, (CD 3) 2 so, C 6 d 6 , CD 3CN, CD 3od and D 2O) Soon, this article became one of the introduction guides for new chemistry lab students To this day, the article is still at the top of the list of "articles read most in 12 months" published on the journal website of J org Chem J Org Chem The most read article source: J org Chem By 2010, Fulmer and other researchers published articles on organotalics to supplement the work of Gottlieb and others (organotalics 2010, 29, 2176) In this paper, the chemical shift data of deuterium solvents (thf-d 8, cd2cl2, toluene-d8, c6d5 ­ Cl, and tfe-d 3) and some gas compounds are added These supplementary contents are of great value to the researchers engaged in the research of organometallic chemistry As time goes on, the chemical industry pays more and more attention to green chemistry, and the selection standards of solvents and other chemical reagents are gradually changing In the 12 principles of green chemistry, it is pointed out that safer solvents should be used as much as possible For example, bio derived solvents, or solvents involved in the life cycle Some pharmaceutical companies have issued solvent selection guidelines in consideration of environmental protection and safety and health of chemical practitioners By 2014, the innovative medicines Initiative (IMI) - chem21 released a comprehensive evaluation of all solvents (green chem 2014, 16, 4546) in order to unify the recommended principles of various agencies and promote the use of industrial preferred solvents in chemical research Solvent safety assessment (high-risk solvents are very common when used in water): Green chem Some solvents are not commonly used in the early stage, such as isopropyl acetate However, due to their relatively safe, sustainable and environmentally friendly characteristics, many solvent selection guidelines recommend the use of these solvents One of the recommended reasons is that these solvents have higher flash points and are more suitable for chemical processes At the same time, it is also a disadvantage, because the reduction of volatility will make the solvent removal process more difficult In addition, the structure of many preferred solvents will produce complex NMR spectra, which will complicate the distribution of resonance of small impurities and make the analysis of NMR spectra more difficult In order to popularize these preferred solvents in chemical process, it is necessary to simplify their identification process in NMR spectrum In 2016, 1H and 13C NMR chemical shift data of new solvents came into being, and their contribution came from whiteker and his colleagues of Dow AgroSciences (org Process res dev., 2016, 20, 661-667) They refer to the recommended solvent guidelines published by chem21, and measure and edit the NMR spectral parameters of various unreported solvents based on the data reported by Gottlieb, kotlyar and nudelman The new MNR chemical displacement table of solvent 1 (green triangle is the recommended solvent and yellow triangle is the problematic solvent) source: org Process res dev now, you can add the new MNR chemical displacement table to your reference guide, because it complements the new data, and also helps you to refer to which solvent is better and worth choosing.