Chloropyridine: "Sweeping" Three Drugs Have a Bright Future

In the field of agrochemicals, there is a chemical structure that can be seen almost everywhere, which is pyridine
.
From the structural point of view, pyridine is a six-membered heterocyclic compound containing a nitrogen heteroatom
.
In terms of application, pyridine can be said to be an important intermediate for "sweeping" the three drugs (pesticides, medicines, and veterinary drugs).
It not only has a large market demand, but also plays an extremely important role in promoting the green development of agrochemical industries
.
The reporter learned that there are many types of pyridine special fine chemicals, and among them, chloropyridine is a high value-added product with great development potential
.
Such products play an important role in agrochemical, daily use, medicine and other fields
.
? Long history? Where there is plant protection, it is there? In the field of agrochemicals, pyridine pesticides are called fourth-generation pesticides, which are highly efficient and low-toxic; they have good environmental compatibility with humans and organisms, and are compatible with pesticides.
Development requirements and trends
.
Compounds containing pyridine ring have become one of the main directions of pesticide creation
.
? Among them, the high-efficiency and low-toxic pesticide chlorpyrifos with huge market capacity, the important intermediate in the production process is the chlorinated pyridine chemicals-2,3,5,6-tetrachloropyridine
.
The first-generation star product of neonicotinoid insecticides, an important intermediate of imidacloprid, is also 2-chloro-5-chloromethylpyridine, a chlorinated pyridine product
.
The promotion history of imidacloprid can be described as brilliant.
Since its listing, it has spread in more than 40 countries around the world in just three years.
Now it can be said that "if there is a plant protection department, there is imidacloprid
.
" Where there is imidacloprid, chloropyridine is of course indispensable
.
In addition to imidacloprid, the insecticide nitenpyram is also a neonicotinoid insecticide with chloropyridine as an important intermediate
.
? In the field of herbicides, chloropyridine is everywhere
.
For example, Diquat, the third largest herbicide in the world after glyphosate and paraquat
.
The important intermediate of this type of herbicide is the chloropyridine product 2-chloropyridine.

.
Experts believe that as the highly toxic pesticide paraquat is banned, and the market’s largest glyphosate is repeatedly involved in carcinogenic disturbances, the market capacity of Diquat will be further expanded
.
The production of diquat per ton needs to consume 900kg of 2-chloropyridine, and 2-chloropyridine will also usher in a broader space for development
.
? Bright prospect? Take over the fifth-generation pesticide? If it can only be used to produce low-variance, low-value-added ordinary agrochemical products, the value of chloropyridine is not worthy of a big book
.
Even for a new generation of green pesticides with a new mechanism of action, the preparation of its key intermediates is still inseparable from chloropyridine
.
? For example, among the latest fifth-generation insecticides, the most famous is DuPont's patented chlorantraniliprole
.
The reporter learned that chlorantraniliprole is a bisamide insecticide.
This type of insecticide is in its own way and is formed separately as "other insecticides
.
" ? Thanks to the addition of chlorantraniliprole, the market performance of "other pesticides" is very eye-catching, and sales have been rising all the way
.
Over time, it is now on par with the once largest neonicotinoid insecticides in the market
.
The key intermediate in the synthesis process is still the chloropyridine chemical 2,3-dichloropyridine
.
? 2,3-Dichloropyridine is a special fine chemical with high added value.
Although the amount is not large, the profit is considerable, and the growth rate is extremely fast in recent years
.
It is understood that DuPont's patent is expected to expire in 2022, when chlorantraniliprole is expected to become an important downstream product of chloropyridine, which will further stimulate demand growth
.
? Widely used? Demand continues to rise? In addition to weeding and insecticide, chloropyridine can also be used to produce nitrogen fertilizer stabilizer tetraclopyr
.
During the application process of nitrogen fertilizer, due to the effects of denitrification, volatilization, leaching, soil fixation and surface runoff, there will be up to 50% loss of nitrogen element, which greatly reduces the effect of nitrogen fertilizer and also causes soil acidification.
, Biodiversity reduction and a series of environmental issues
.
The nitrogen fertilizer stabilizer aims to improve the utilization rate of nitrogen fertilizer and prevent the loss of nitrogen
.
In this process, the role of chloropyridine is essential
.
As nitrogen fertilizer is the "big brother" of the chemical fertilizer market, global nitrogen fertilizer consumption accounts for more than 60% of all chemical fertilizer consumption, which gives chloropyridine a lot of room for development
.
? The role of chloropyridine is far not limited to industry, it can also be seen everywhere in the field of daily use and medicine
.
The reporter learned that chlorinated pyridine can be used to produce the fungicide ZPT, which is widely used in shampoos, including Head & Shoulders, Rejoice and other well-known brands that contain this ingredient
.
In the field of medicine, chloropyridine is also an important intermediate of antihistamine drugs such as pheniramine, central stimulant Ritalin, trazodone, and antiarrhythmic drug disopyramide
.
The reporter learned that China is the main producer of chloropyridine
.
In the next few years, products such as 2-chloropyridine and tetrachloropyridine will be further scaled up and concentrated, and the production capacity of various chloropyridines will reach 40,000 to 60,000 tons
.
From a global perspective, the global consumption of 2-chloropyridine is 40,000 tons, the global consumption of tetrachloropyridine is 50,000 tons, the global consumption of 2,3-dichloropyridine is 18,000 tons, and the global consumption of 2-chloro-5-chloromethylpyridine is 28,000.
Tons, the demand for various chloropyridines is about 150,000 tons, and the market space is huge
.
? "Let you change the product, I will not move
.
" Chloropyridine's record in the field of "three drugs" is not unfavourable .
According to the "Petrochemical and Chemical Industry Development Plan (2016~2020)" and the "Thirteenth Five-Year Development Plan for the Pesticide Industry", in the future, China's pesticide product structure will undergo in-depth adjustments, and the output of environmentally friendly pesticides will increase to more than 70%
.
By then, the new green and environmentally friendly pesticides will usher in a new era of their own.
As an important intermediate, chloropyridine will also embark on a new journey
.