Development of double response vesicles in Fuzhou University for tumor imaging and photodynamic therapy

Recently, Professor Song Jibin, a Key Laboratory of the Ministry of education of food safety and biological analysis, from the school of chemistry, Fuzhou University, cooperated with Professor Yang huanghao to develop double response vesicles to realize the imaging and photodynamic therapy of tumors The research paper was published in angel Chem Int ed (DOI: 10.1002 / anie 201912768) under the title of "ultrasound activated vehicle of Janus Au MnO nanoparticles for promoted tumor penetration and sono chemical therapy of orthotopic lever cancer" School of chemistry of Fuzhou University is the first completion unit The first author is Lin Xiahui, a 17 level doctoral student Sonodynamic therapy (SDT) is a kind of ultrasound-based therapy, which can kill cancer cells by producing ROS and cavitation However, the current nano platform for SDT can not give full play to the advantages of ultrasound (US) due to its large size, low sensitivity and limited therapeutic effect Moreover, the abnormal blood vessels and dense extracellular matrix of the tumor restrict the tissue penetration of the acoustic sensitizer and further limit the efficacy of SDT In order to solve these problems, the author designed a new and efficient sound sensitive agent, which is formed by the assembly of Janus Au MnO nanoparticles (jnps) modified with PEG and ROS sensitive polymers to form vesicles with double response of us and glutathione (GSH) Under US irradiation, the vesicles were broken down into small Janus Au MnO nanoparticles (NPS) with penetration promoting ability Subsequently, MnO degradation and release of smaller Au NPs (as many hole nucleation sites) and Mn 2 + (for chemokinetic therapy) triggered by overexpression of GSH in tumor microenvironment led to the formation of a large number of reactive oxygen species (ROS), which inhibited the growth of liver tumor in situ by cooperating with SDT / CDT This intelligent nano platform can also perform dual-mode photoacoustic imaging in the second near infrared (NIR) window and t 1-mr imaging due to the release of Mn 2 +, which provides a new idea for in vivo imaging guided deep tumor precise treatment drugs.