Direct ionization mass spectrometry technology for pesticide residue detection (in-situ mass spectrometry)

Mass spectrometry technology is a common method in analytical testing technology that has high sensitivity, good specificity, and fast response speed at the same time

The atmospheric pressure direct mass spectrometry technology generally refers to the emerging mass spectrometry technology that can directly analyze various complex matrix samples without sample pretreatment

Atmospheric pressure direct mass spectrometry generates primary ions with a certain energy, and realizes the transfer of energy and charge in the complex matrix through certain steps, and selectively absorbs the energy and charge according to the difference in the physical and chemical properties of the analyte molecule, thereby triggering the complex matrix Ionization of the analyte in the sample

In terms of practical applications, miniaturization and integration while maintaining the performance of the ion source is one of the important development directions in this field

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Figure 2-8 ASAP-MS/MS spectrum of phoxim in strawberry samples

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The principle of DART is to desorb and ionize the excited atoms generated by the discharge of a carrier gas (such as helium or nitrogen) under normal temperature and pressure, and then detect by mass spectrometry or tandem mass spectrometry

(1) Direct analysis

(2) Easy to operate and save manpower

(3) Green, low-carbon, and non-destructive

(4) Liquid, solid, gas samples, or samples of any shape (such as leaves, plants, agricultural products, packaging materials) can be analyzed under normal pressure

(5) It can ionize active components, drugs, poisons, carbohydrates, lipids and residual organics with polarity, medium polarity and weak polarity at the same time

(6) No obvious addition salt ions, no multi-charged ions

(7) The sample analysis is very simple

(8) Compatible with many mainstream mass spectrometer manufacturers (such as AB SCIEX, Agilent, Bruker, ThermoFisher, Wa-ters, Shimadzu, JEOL, etc.