He Xiaopeng, Professor of East China University of science and technology, made research progress in biomedical application of molecular assembly materials

Recently, the research group of Professor He Xiaopeng of the joint research center of feilinga Nobel scientists of East China University of science and technology has made progress in the biomedical application of molecular assembly materials, and relevant achievements have been published in the Journal of the American Chemical Society and Applied Chemistry of Germany In clinic, the stubborn infection of multi drug resistant bacteria (superbacteria) has become one of the most important factors threatening the life safety of patients in ICU However, the research and development of traditional antibiotics lags far behind the emergence of bacterial resistance Therefore, how to develop efficient and novel non antibiotic antibacterial strategies has become a major challenge for global biomedical practitioners Based on the above key clinical problems, the researchers have developed molecular self-assembly targeting antibacterial materials based on new materials with controllable structure and self-assembly antimicrobial peptide microspheres based on cyclodextrin, which have achieved in vitro and in vivo killing of a variety of gram-positive and gram-negative superbugs Based on the construction of two-dimensional glycosyl self-assembly materials and the work foundation of photodynamic and photothermal dual-mode anti Pseudomonas aeruginosa (adv funct Mater 2019, 29, 1806986), the research team and Professor Mai Yiyong of Shanghai Jiaotong University have synthesized graphene nanobelt materials with controllable structure and verified its excellent photothermal properties (angel Chem Int ed 2018, 57 , 3366), and further cooperated with Professor Juyoung Yoon of Ewha Womans University in South Korea to synthesize cationic porphyrin derivatives Through a series of in vitro and in vivo experiments, it has been proved that the material can be combined to the bacterial surface through charge attraction, and then through the photothermal properties of photoinduced nanoribbons and the photodynamic properties of porphyrins, it can synergistically inhibit the growth of a series of gram-positive and gram-negative drug-resistant bacteria, and further It has realized the efficient removal of superbacteria from mouse epidermis infection, and its performance is superior to that of conventional antibiotics (see the figure below) The above work provides a class of non antibiotic antibacterial materials for clinical super bacterial infection, and the relevant results are published in German Applied Chemistry (angel Chem Int ed 2020, DOI: 10.1002 / anie 201913506) (source: angelw Chem Int ed.) in recent years, the development of antimicrobial peptides has been widely concerned by the biomedical industry However, bioactive peptide compounds generally have the defects of poor membrane permeability and in vivo stability Based on the above problems, the research team cooperated with Professor Juan Xie of cashan Normal University in France and Professor Jonathan Sessler of University of Texas Austin in in the United States to synthesize cyclodextrin and naphthalene bromide modified by pyranonitrile derivatives/ Fluorescein modified antibacterial peptide microspheres were constructed by self-assembly of naphthalene bromide and cyclodextrin and subsequent amphiphilic self-assembly Compared with the unassembled antimicrobial peptides, the constructed peptide microspheres can enhance the fluorescent labeling of Staphylococcus aureus and Escherichia coli, and show stronger antibacterial effect on the two kinds of bacteria In addition, the strategy has also been proved to be suitable for enhanced fluorescence labeling of cell apoptosis and mitosis The above work was published in J am Chem SOC 2020, DOI: 10.1021/jacs.9b11207 The above work provides a new chemical strategy for the treatment of clinical superbacteria In addition, the research team and collaborators were invited to publish the biomedical application review of targeted molecular probes and assembly materials on chem SOC Rev 2020 (DOI: 10.1039 / c8cs00118a) and adv funct Mater 2020 (DOI: 10.1002 / ADFM 201907906) He Xiaopeng also won Thieme Chemistry Journals award in 2020 The research work was mainly completed by Yu Zhihao, Jiao Jinbiao, the graduate students of our school, and Dr Hu Xile, the young teacher, and so on, with the careful guidance of academician Tian He The work of biology and microbiology was guided and supported by Li Jia, researcher of Shanghai Institute of medicine, Chinese Academy of Sciences, Zang Yi, and Chen Daijie, Professor of Shanghai Jiaotong University The research work was supported by major research programs of NSFC, science fund for outstanding young scholars, major science and technology projects of Shanghai, international cooperation and exchange projects of Shanghai, and "111" talent introduction program.