Illustrated documents @ org lett artificial natural products: a wonderful combination of genes

The highlights of the combinatorial biosynthesis of daurichronic acid and its chlorides (http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b01288; doi: 10.1021/acs.orglett.7b01288): 1) human assembly of genes of three species and Realization of heterologous expression of daurichronic acid; 2) the generation of artificial natural products with higher activity than the target compounds Figure 1: the idea of this paper (some pictures are from orglet) Introduction: daurichronic acid (DCA, 1) is a kind of terpenoid compound isolated and purified from Rhododendron dauricum, which has highly effective anti HIV activity In this paper, researchers amplified stbac (PKS and PT), DCAS (cyclase) from Stachybotrys bisbyi, R dauricum, Fusarium sp, Ascd (halogenase) gene; two plasmids, padea stbac DCAS and psusa ascd, were constructed (see Fig 1: a); daurichromatic acid and its artificial natural product chloride analogue were heterologously expressed in Aspergillus oryzae (see Fig 1: b); and then compound 3 was mapped The activity of the compound was identified, and the compound 3 with higher activity was found (see Fig 1: C) Rhododendron is a protected species, which can not be exploited without limitation, and the amount of extraction and separation of compounds from plants is large, so it is a new way to synthesize active compounds by biosynthesis Moreover, the novelty of this paper lies in the discovery of artificial active natural products, which will expand the scope of traditional natural products and provide a new way for the discovery of new lead compounds Extended reading of the research on the biosynthesis of terpenoids from mixed sources is shown in biosynthosisof fungal meroterpenoids, unusualchemities in fungal meroterpenoids biosynthesis unusualchemities in fungal meroterpenoids biosynthesis It is worth mentioning that these two reviews and this paper are the same corresponding authors, and those who are interested can understand them by themselves Bactericidal Kinetics of Marine-Derived Napyradiomycins againstContemporary Methicillin-Resistant Staphylococcus aureus Previous recommendations of biosynthesis series: 1 The highest level of laying eggs with the help of @ NAT com: preparation of active compounds by engineering bacteria 2: Fig 3: Fig 4: Fig 4: biosynthesis of anisomycin, a pyrrolidine protein synthesis inhibitor of PNAs: new gene integration and hidden biosynthesis steps 5: Figure 6: Figure 6: Figure 6: Figure 6: nature energy, I will save you with microorganisms against contemporary methicillin resistant Staphylococus aureus Note: due to the limited ability of the author, please leave a message if there are any questionable points above, and we will contact you actively! Reprint please indicate: CBG information, Tao Xiaohua Welcome to the "CBG information" WeChat official account and QQ group: 498263368 (click join to join CBG- [biosynthesis]: https://jq.qq.com/ _wv=1027&k=49bs909, enter the secret number: Name + unit or research direction)