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9.
1.
2 Metabolism and Toxicology
9.
1.
2.
1 Metabolism in the body
DES can be absorbed by the digestive tract after oral administration, but cattle and sheep are destroyed in the rumen, and the first pass effect is more serious
.
DES is quickly excreted by the kidneys after being absorbed, and it lasts for a short time in the body.
ZER metabolism produces TAL and ZAN
.
The main metabolite of ZER is ZAN
There are two isomers of ZON metabolites: a-ZOL and β-ZOL
.
Zollner and others detected ZON and its metabolites in pork
9.
1.
2.
2 Toxicology and adverse reactions
DES is a lipophilic substance, relatively stable, not easily degraded, and easy to remain in human and animal fat and tissues.
Long-term use can cause liver damage
.
In addition, DES is also difficult to degrade in water and soil, and it can also cause other chronic diseases by accumulating in the body through the food chain
ZER has embryotoxic effects on rats
.
After ZER is discharged from the animal body, it can also cause secondary pollution and environmental pollution through drinking water and food
Animals usually ingest ZON by feeding contaminated grains, corn, wheat and other food crops and feed
.
The toxicity of ZON is mainly manifested in two aspects, one is developmental reproduction toxicity, the other is that it can participate in the process of tumorigenesis; in addition, it also has immunotoxicity, hepatotoxicity, neurotoxicity and so on
