Nat. Commun.: a new method for the synthesis of conjugated polymers for the photothermal treatment of tumors

Liang Gaolin and Wang Yucai from the school of chemistry and materials science, University of science and technology of China and the school of Life Science reported a new method of convenient synthesis of conjugated polymer, which was used in the photothermal treatment of tumor and achieved excellent photothermal treatment effect The research results were published in nat.commun (DOI: 10.1038/s41467-019-09226-6) under the title of "facile synths of regulated polymers for photothermal tumultherapy" Researchers have been working on the synthesis of photothermal materials with high light utilization and photothermal conversion efficiency In addition to some carbon based nanomaterials, conjugated polymers are promising photothermal materials However, there are few monomers for conjugated polymers and conjugated polymers with excellent photothermal properties Based on the CBT Cys click condensation reaction, Professor Liang Gaolin's research group redesigned the raw materials and synthesized the conjugated polymer ppbbt and its derivatives with good photothermal conversion properties in high yield with relatively mild reaction conditions Under the irradiation of xenon lamp, ppbbt and SWCNTs have comparable heating rate and photothermal conversion efficiency By using nano precipitation technology, Professor Wang Yucai's research group wrapped ppbbt to get nano particle NP ppbbt which can be stably dispersed in water The results of in situ tumor model mice show that the nanoparticles can be passively targeted and enriched in tumor site and have excellent photothermal treatment effect This new method provides a convenient way to synthesize more conjugated polymers, and has great application prospects in biomedical or optoelectronic fields The first authors of this paper are Chen Peiyao, Ph.D., School of chemistry and materials science, University of science and technology of China, Ma Yinchu, Ph.D., School of life sciences, and Zheng Zhen, Ph.D., School of chemistry and materials science Professor Wang Yucai and Professor Liang Gaolin are co correspondents The research was supported by national key research and development program (2016yfa040904), National Science Foundation for Distinguished Young Scholars (21725505), innovation research group (81821001) and general fund (21675145, 51773191 and 51573176).