Near infrared two region nano therapeutic diagnostic materials for cancer imaging and treatment

At the beginning of this year, an article published in CA: a cancer journal for clinicians (DOI: 10.3322 / CAAC 21551) predicted the development of cancer in the United States in 2019 It pointed out that 1762450 new cancer cases will be diagnosed in the United States in 2019, and 606880 patients will die of cancer The latest national cancer statistics released by the National Cancer Center in January also show that cancer has become one of the most important threats to human health At present, the treatment methods for cancer are mainly divided into surgery, chemotherapy, radiotherapy, etc., but these methods inevitably have side effects on the body while treating cancer Therefore, from the perspective of minimizing the side effects of treatment on the human body, scholars put forward the concepts of targeted treatment and surgical operation accuracy to reduce the pain of patients in the treatment process Better treatment can further increase the survival rate of cancer patients Fig 1 Composition and working principle of Psy materials (photo source: chem SCI.) recently, Professor Sun Yao of central China Normal University joined hands with Professor Jong Seung Kim of Korea Koryo university with the title of "a nano cocktail of nir-iiemissive fluorophore and organoplatinum (II) metalcycle for efficient cancer imaging and therapy" in Chem SCI (DOI: 10.1039/c9sc02466b) reported a kind of near-infrared two region nano material psy, which can be used in the integration of cancer diagnosis and treatment This material is composed of a large ring molecule P1 containing organic platinum, a near-infrared two region dye sy1030 and an FDA approved polymer Pluronic F127 The organic combination of the three materials makes Psy It has ideal stability, solubility, biocompatibility and cancer cell targeting Based on the characteristics of Psy, our team has successfully proved that the material has better cell penetration, anti-cancer effect and lower side effects than the traditional platinum based drug cisplatin At the same time, the addition of sy1030 enables the material to provide a higher signal-to-noise ratio image in the imaging process Fig 2 A) TEM image of Psy; b) particle size analysis of Psy; c) stability of Psy in different environments; d) release efficiency of platinum in psy; E) absorption and emission profile of Psy; F) stability of Psy compared with ICG; g) cell penetration of Psy; H) antitumor effect of Psy (picture source: chem SCI.) F127 compared with P1 and sy1030 After assembly, spherical particles with a size of about 110 nm (Fig 2a, 2b) will be formed, and the structure has good stability (Fig 2C), but the stability of the structure will not affect the release of drug molecules The experimental results show that more than 50% of Pt (II) will be released from psy nanoparticles within 24 hours (Fig 2D), while the optical properties of sy1030, another material wrapped by F127, are well preserved after psy formation (Fig 2e), and it has better stability than the FDA approved near-infrared one area treatment drug ICG (Fig 2f) In addition, Psy can be quickly phagocytized by cells (Fig 2G) and because P1 can cross bind with DNA, Psy also shows high anti-cancer characteristics (Fig 2H) Fig 3 A) nir-ii imaging of tumor treatment in mice; b) tumor tissue weight in mice after drug injection; c) survival rate in mice after drug injection (picture source: chem SCI.) further in vivo experimental results show that psy has longer blood circulation time compared with cisplatin, a traditional anticancer drug, so it can provide better anticancer effect Compared with the near-infrared materials, Psy with two-zone near-infrared characteristics can obtain better contrast images Based on the above experimental results, the authors believe that psy can be applied to the treatment and diagnosis of cancer, and verify this possibility They found that psy can be significantly enriched in the tumor area after entering the mice by mouse imaging (Fig 3a), and has better anti-cancer effect and lower side effects than cisplatin (Fig 3b, 3C) Although the most effective and direct cancer treatment is surgery, and in theory, the tumor cells can be completely removed by surgery, but in the actual operation process, surgery often causes irreversible and unnecessary damage to patients, and the side effects of chemotherapy and radiotherapy often aggravate the pain of patients The emergence of targeted therapy and precise surgery enables patients to get rid of cancer in a more comfortable treatment process The psy materials reported by Professor Sun Yao and Professor Jong Seung Kim have better targeting than existing cancer treatment drugs, and can reduce the side effects of drugs as much as possible In addition, the material has the characteristics of two zone near-infrared imaging, which can provide more effective information in cancer diagnosis and treatment through optical imaging and other means, and provide more help for doctors' accurate treatment and operation Full text author: F Ding, Z Chen, W Kim, A Sharma, C Li, Q Ouyang, H Zhu, G f.yang, Y sun and J S Kim.