Normal-valent halogen compounds and the reactions they participate in (3)

Example 4

Application process: 35% perchloric acid aqueous solution was added dropwise to a solution of compound A (80g) in ether (1000mL) at room temperature , and then stirred overnight

The R&D personnel immediately discussed with the supervisor, and the modified operation description was as follows: At room temperature, 35% perchloric acid aqueous solution was added dropwise to a solution of compound A (80g) in ether (1000mL), and then stirred overnight

Finally, the response was approved

Example 5

Application process: At 25℃, add azobisisobutyronitrile (AIBN) and N-bromosuccinimide (NBS) to compound A, diethyl phosphate and N, N-diisopropyl at one time Diethylamine (DIPEA) in the mixed liquid, and then the temperature is raised to 65-75°C

Remarks: This is a free radical reaction.

Example 6

Application process: Dissolve the reaction substrate A and RuCl ₃ ·H ₂ O in a mixture of acetonitrile, EtOAc and H ₂ O according to the prescribed amount, add NaIO4 in batches under an ice water bath, and control the internal temperature of the reaction at 10～25℃ After adding, stir overnight at room temperature

Remarks: Use sodium sulfite or sodium thiosulfate to quench excess sodium periodate