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Naphthylacetic acid (naphthylacetic acid) is also known as 1-naphthylacetic acid and a- forbidden acetic acid.
The molecular formula is C 12 H 10 O 2 , the molecular weight is 186.
21, and the structural formula is
1.
Product performance
White needle-like crystal or crystalline powder; odorless, moderately toxic; soluble in hot water, ether , acetone , chloroform and alkali solution, slightly soluble in cold water; melting point 134.
5～135.
5℃
.
2.
Production principle
Refined naphthalene is prepared by condensation with chloroacetic acid under the catalysis of aluminum powder
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Condensation reactor, acidification pot, storage tank, recrystallization pot, filter, drying box
.
6.
Production process
Put chloroacetic acid and refined naphthalene into the condensation reaction kettle, add aluminum powder with a purity of 99.
8%, and heat to 240-250°C to make the reaction boil for about 9h
.
The HCl released by the reaction is absorbed by water to produce hydrochloric acid as a by-product
7.
Laboratory preparation method
In a three-necked flask, add 750 mL of methanol , 240 mL of water, and 175 g of sodium cyanide , and after the mixture is uniform, add 350 g of a-chloromethyl naphthalene
.
Stir at room temperature for 6 minutes, and then heat to reflux for 2 hours
In another reaction flask, add 750 mL of 72% acetic acid and 48 mL of 87% sulfuric acid, and heat to boiling
.
Mix 340g crude a-naphthaleneacetonitrile with 750mL 72% acetic acid as a suspension, and slowly add it to the reaction flask, keeping the temperature above 100%
8.
Product Standard
9.
Product use
Used in the pharmaceutical industry and organic synthesis
.
In agriculture, it is used for accelerating germination and growth, and it is also used to protect cotton buds and bolls
.
Its sodium salt is a plant growth stimulant
.
10.
Security measures
(1) The raw material naphthalene is poisonous, and the maximum allowable concentration in the workplace is 0.
001%
.
Chloroacetic acid is extremely toxic, with an oral LD 50 of 76 mg/kg in rats, which is highly irritating and corrosive
.
Condensation equipment should be airtight, operators should wear labor protection equipment, and strengthen ventilation in the workshop
.
(2) Packed in woven bags lined with plastic bags, and stored in a cool and dry place
.
Store and transport in accordance with drug regulations
.
