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Semicarbazide hydrochloride, also known as semicarbazide hydrochloride, has a molecular formula of CH 6 CIN 3 O, a molecular weight of 111.
53, and a structural formula of
1.
Product performance
White crystal, soluble in water, showing acidic reaction; insoluble in absolute ethanol and ether , soluble in dilute ethanol; melting point 172~175℃ (decomposition)
.
2.
Production principle
After the hydrated fat is condensed with urea, the product is acidified by adding hydrochloric acid
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Condensation reaction kettle, acidification kettle, filter, drying box
.
6.
Production process
Add 282kg of hydrazine hydrate into the enamel reactor, turn on the steam heating until the temperature reaches 85C±50°C, then add 41kg of urea and stir for 30min
.
Raise the temperature of the kettle to 105°C±5°C, reflux for 2h, and then add 193kg of urea to the kettle
7.
Laboratory preparation method
In the reaction flask, add 100g of Hydrate and heat to 80-90°C, add 14.
5g of urea, stir for 30min, heat up to 100-110°C, reflux for 2h and then add 50g of urea, continue refluxing reaction for 2h
.
After cooling to 10°C, let it stand, filter, add 275g hydrochloric acid to the filtrate, let it stand, and filter with suction to obtain semicarbazide hydrochloride
8.
Product Standard
9.
Product use
Used as a raw material in the pharmaceutical industry, for the synthesis of furan drugs such as nitrofuran and nitrofuran
.
It is also used as a reagent for the determination of ketones and aldehydes, a chromatographic analysis reagent and a solvent for the separation of hormones and essential oils
10.
Security measures
(1) The raw material hydrazine hydrate is an inorganic alkaline corrosive substance, which is toxic and will cause spontaneous combustion and explosion when it comes in contact with oxidants
.
The condensation reactor should be airtight, the operator should wear labor protection equipment, and the workshop should be ventilated
(2) This product is low-toxic, packed in a woven bag lined with a plastic bag, and stored in a cool, ventilated place
.
Store and transport as general chemicals
.
