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M-aminophenol (m-amino phenol), also known as 3-hydroxy-aniline (3-hydroxyaniline), 3- aminophenol, of formula C .
6 H .
7 NO, molecular weight of 109.
13, the formula
1.
Product performance
White crystal; melting point 123°C, boiling point 164°C (1.
46kPa); soluble in hot water, ethanol , ether and amyl alcohol , slightly soluble in water and benzene; easily oxidized, the color turns black when stored; highly toxic!
2.
Production principle
Nitrobenzene is reduced by sulfonation to obtain m-aminobenzenesulfonic acid, and then acidified by alkali melting to obtain m-aminophenol
.
3.
Process flow
4.
Technical formula (kg/t)
5.
Main equipment
Sulfonation reactor, crystallization pot, filter, reduction pot, alkali melting pot, acidification pot, storage tank, vacuum distillation pot
.
6.
Production process
Put 123 parts of nitrobenzene into the sulfonation reaction kettle, slowly add fuming sulfuric acid dropwise, and stir while adding
.
After the addition is complete, the temperature is increased to 105°C, and the reaction is carried out for 2 hours
After the sulfonation is completed, the cooled reactant is slowly poured into a tank containing 200 parts of water and 300 parts of crushed ice in a trickle while stirring
.
Then add 200 portions of salt in batches within 2 to 4 hours
The acidified liquid was cooled to below 10°C, and crude meta-aminophenol crystals were precipitated
.
The crude product is purified by vacuum distillation, and the fractions at 178-182°C/1000Pa are collected to obtain the pure product m-aminophenol
7.
Product Standard
8.
Product use
Used in the production of antioxidants, stabilizers, developers and color films
.
In medicine, it is used in the manufacture of anti-tuberculosis drug para-aminosalicylic acid; also used in the manufacture of azo dyes and fluorescent whitening agents (such as the production of fluorescent whitening agents EGM, ACB, EF, etc.
9.
Safety measures
(1) The raw material nitrobenzene used in production is poisonous.
Concentrated sulfuric acid is a first-grade inorganic acid corrosive substance.
The product has the double toxicity of phenol and aniline and is a highly toxic organic substance
.
The equipment should be closed, the operator should wear labor protection equipment, and the workshop should be well ventilated
.
(2) Packed in iron drum lined with plastic bag, sealed and protected from light in a cool and dry place, pay attention to heat, sun and moisture
.
Store and transport in accordance with toxic chemicals regulations
.
