Production process and product use of 2-chloro-4-nitrobenzoic acid

2-chloro-4-nitrobenzoic acid (2-chloro-4-nitrobenzonic acid) , also known as o-chlorostyrene, p-nitrobenzoic acid, of the formula C _.
7 H _.
4 CINO _.
4 , a molecular weight of 201.
57, the formula

1.

White or light yellow needle-like or powder crystals; toxic and irritating; melting point 142～143℃ (or 139～141℃); soluble in hot water, ethanol and hot benzene
.

2.
Production principle

After p-nitrotoluene is chlorinated, it is then oxidized with potassium permanganate to obtain the product
.

3.

4.

5.

Chlorination reaction kettle, washing kettle, hydrogen chloride absorption tower, centrifuge, oxidation kettle, neutralization crystallization kettle dryer
.

6.
Production process

Put 485kg of p-nitrotoluene into the chlorination reactor, heat to 70°C, and add 16kg of ferric chloride
.

In the oxidation reactor, put 1800L water and 60kg sodium hydroxide, add 80kg 2-chloro-4-nitrotoluene under stirring, heat to reflux, and add 170kg potassium permanganate in batches
.

7.
Product Standard

8.

Assay: Titrate with potassium hydroxide ethanol standard solution, with phenolphthalein as indicator
.

In the formula: c——molar concentration of potassium hydroxide standard solution, mo/L;

V——The volume of potassium hydroxide standard solution consumed by the sample, mL;

G——The mass of the sample, g
.

9.

Intermediate for drug synthesis, such as for the synthesis of rivanol; also used as a disinfectant and preservative
.

10.
Security measures

(1) The raw materials are toxic to nitrotoluene and chlorine, and the products are organic drugs.
The production equipment should be sealed, the operators should wear labor protection equipment, and the workshop should be well ventilated
.
The tail gas of the chlorination reaction should be absorbed by water
.

(2) The product is toxic and explosive.
It is packaged in a plastic-lined iron drum, sealed and stored in a cool and dry place, to prevent fire, smoke, impact, heat and sun
.