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Diabetes is one of the three chronic diseases threatening human health in the world
.
According to epidemiological surveys, the disease directly or indirectly affects the health and quality of life of more than 425 million people worldwide .
The increase in the prevalence of diabetes directly leads to an increase in the rate of tooth loss in patients, which in turn leads to a surge in the demand for oral implant restoration .
At the same time, the continuous impairment of bone metabolism in diabetic patients leads to prolonged healing time after implantation and poor implant - osseointegration; even in the case of controlled blood sugar, due to the disease characteristics of energy metabolism disorders, diabetic patients are at risk of inflammation around implants.
At present, conventional implant surface modification strategies mainly focus on the development of antibacterial coatings or functional interfaces for adjusting bone homeostasis, but the above strategies often have little effect in the complex and changeable diabetic microenvironment
.
In recent years, as researchers have deepened their understanding of the pathological microenvironment of diabetes, it has been revealed that in addition to high glucose and persistent chronic inflammation, excessive oxidative stress and imbalance of immune homeostasis in the implants of diabetic patients can also interfere with the energy of macrophages.
Metabolizes, destroys the activity of endogenous growth factors, damages the regeneration potential of related cells around the implant, and ultimately interferes with the process of implant - osseointegration in diabetic patients , resulting in treatment failure
Recently, the research team of Professor Ji Ping of Chongqing Medical University / Deputy Chief Physician Chen Tao published a research article "Safeguarding Osteointegration in Diabetic Patients: A Potent "Chain Armor" Coating for Scavenging ROS and Macrophage in Advanced Functional Materials .
Reprogramming in a Microenvironment-Responsive Manner" (10.
Figure 1.
Schematic diagram of the synthesis and function of Ce-TA " chain mail " .
Figure 2.
Synthesis and partial characterization of Ce-TA " chain mail " coating
Synthesis and partial characterization of Ce-TA " chain mail " coating
Figure 3.
Ce-TA coating releases in response to the microenvironment and simulates SOD and CAT enzymes
Ce-TA coating releases in response to the microenvironment and simulates SOD and CAT enzymes
Figure 4.
Ce-TA reshapes the microenvironment of high-glycemic inflammation cases into a regenerative microenvironment
Ce-TA reshapes the microenvironment of high-glycemic inflammation cases into a regenerative microenvironment
Figure 5.
Ce-TA drives reprogramming of macrophages
Ce-TA promotes osseointegration at the implant - bone interface in diabetic rats .
Ce-TA drives reprogramming of macrophages
Figure 6.
Ce-TA promotes osseointegration at the implant - bone interface in diabetic rats .
The first author of the thesis is He Qingqing, a graduate student of the School of Stomatology of Chongqing Medical University.
Chen Tao, deputy chief physician of the School of Stomatology of Chongqing Medical University, is the corresponding author of the article, and Chongqing Medical University is the first completion unit
.
This research was supported by the National Natural Science Foundation of China ( 32071362, 31871464 ) and the Chongqing Municipal Education Commission Science and Technology Research Project ( KJQN201900407 , KJQN201900415 ) and other projects
.
Original link: https://onlinelibrary.
wiley.
com/doi/10.
1002/adfm.
202101611
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