Professor Wang Qigang and his collaborators of Tongji University develop new materials to simulate neutrophil lysosomes for cancer treatment

As the first natural immune cell migrating to tumor tissue, neutrophils can kill abnormal cells immediately and activate long-term specific adaptive immune response Therefore, enzyme-mediated reactive oxygen species (ROS) increase in neutrophils is a promising strategy for tumor immunotherapy Recently, Professor Wang Qigang of the school of chemical science and engineering of Tongji University has designed a nano gel, which triggers the self-assembly of oligopeptides around iron oxide nanoparticles through surface phosphatase to simulate the production of neutrophil lysosomes The cascade reaction of superoxide dismutase (SOD) and chloro peroxidase (CPO) in bioactivated nanoscale can convert reactive oxygen species into hypochlorite (HClO) and 1 O 2 in tumor tissue, which can be used to treat tumors without external energy activation Relevant research results were published in nature communications (DOI: 10.1038 / s41467-018-08234-2) under the title of "cascadeenzymes within self assembled hybrid nominal mimized neutral lysomesfor single oxygen raised cancer therapy" The only corresponding author of the paper is Tongji University The first co authors of the paper are Dr Wu Qing and Dr he Zhigang The co authors are Professor Li Jiyu from the 10th people's Hospital Affiliated to Tongji University, Associate Professor Wang Xia and Professor Wang Qigang from the school of chemical science and engineering Cancer remains the leading cause of death, causing millions of deaths worldwide each year Traditional clinical cancer treatment, including surgery, chemotherapy and radiotherapy, has some limitations, such as toxic side effects on normal cells, drug / radiation resistance, and increased incidence of tumor growth The long-term evolution of human innate immune system, through molecular oxygen dependent cell inactivation lysozyme related digestion and release of immune cytokines, has inspired a new and efficient biochemical method for cancer treatment Neutrophil dependent cell inactivation usually occurs on neutrophil lysosomes hundreds of nanometers in size, and its reactive oxygen species activity is determined by the biocatalytic system of myeloperoxidase (MPO), hydrogen peroxide (H 2O 2) and halide ions By simulating the form of neutrophil lysosome, the researchers used the superoxide dismutase and chlorinated peroxidase in Supramolecular Gel structure as a mimic neutrophil lysosome, and transformed the tumor microenvironment into a relatively high level of ROS, thus constructing a multifunctional SOD/CPO loaded nano gel system (SCNG) for tumor therapy Using EPR technology and temp as trapping agent, the researchers simulated the internal environment in the NaCl solution of H2O2 to detect and verify the signal of 1O2 produced by scng The results show that the cascade SOD and CPO in scngs can effectively transform the active oxygen in tumor tissue into the 1O2 component of anti-tumor therapy Based on the experimental results, the researchers hypothesized that the enzyme dynamic therapy (EDT), which makes full use of the enzyme reaction in tumor area, can control the production of 1O2 to treat cancer.