[quick news] crystal structure of key enzymes in chlorophyll synthesis on November 1, 2019 is revealed for the first time

The crystal structure of the key enzyme of chlorophyll synthesis was revealed for the first time by the research group led by Cheng Qi, Ph.D of the Institute of biotechnology, Chinese Academy of Agricultural Sciences The three-dimensional crystal structure of the key enzyme of chlorophyll biosynthesis, the photoresist orthochlorophyllin ester oxidoreductase, was revealed for the first time, which made a major breakthrough in understanding how the protein structure controls the catalytic action of important optical driving enzymes The results were published in the science journal Nature "This study provides a key missing link between protein structure and excited state chemistry of the enzyme, which is of great significance to the engineering design of photocatalysis, biocatalyst and related protein small molecule inhibitors." Cheng Qi, co-author of the results, said that this work also paved the way for providing detailed calculation and analysis of quantitative conversion of light energy to chemical energy, and the description of the catalytic effect will be more complete, which is also a major challenge for enzymology at present Http://digitalpaper.stdaily.com/http_ / 31 / content_ HTM? Div = - 1 academician Rao Zi of the Chinese Academy of Sciences and analysis of African swine fever virus structure: like Russian dolls, many basic problems around African swine fever need to be solved urgently Rao Zi works with the team and other research institutions to collect a large amount of data through 3D The structure of African swine fever virus was obtained "The virus has five layers and looks like a Russian doll." Rao Zihe held a 3D model and explained it to the participants at the Forum on that day African classical swine fever virus (ASFV) has five unique structures: outer membrane, capsid, inner membrane, putamen and inner layer The virus particles contain more than 30000 protein subunits Rao Zihe said that this is the first time to see the structure of African classical swine fever virus on the atomic structure, "can help us design vaccines." Http:// the conductivity of copper-based superconductors has nothing to do with the thickness Zhang Yuanbo, Department of physics, Fudan University, obtained the conductivity data of single-layer copper-based superconductors under the two-dimensional limit for the first time, proving that they have the same superconductivity as bulk copper-based superconductors On October 31, the study was published online in the journal Nature Combining transport and scanning tunneling microscopy and spectroscopy data, the team found that the superconducting state, pseudogap state, charge density wave state, and model insulation state in the single-layer Bi-2212 phase diagram at the two-dimensional limit were also consistent with the block behavior This conclusion provides a more solid experimental basis for the two-dimensional theoretical model of HTS and the effectiveness of the existing research on the surface of HTS bulk materials, and expands the field of vision of the research on two-dimensional materials Http://news.scienceet.cn/htmlnews/2019/10/432129.shtm new gene therapy has successfully saved the patients with lymphoma from using a novel gene therapy to treat diffuse large cell lymphoma for the first time in Freiburg University Hospital, Germany, with great success Through the so-called car-t cell therapy, the patient's immune cells (i.e lymphocytes) are genetically modified in the laboratory to recognize and resist cancer cells The preliminary examination after treatment showed that the effect was very good So far, in Germany, car-t cell therapy has only been approved for several forms of leukemia and lymphoma, and usually only for patients who have no effect on standard therapy A team led by Tony katman, director of the Institute of gene therapy at the University Hospital of Freiburg, is exploring a major EU project to implement car-t cell therapy more safely Http://digitalpaper.stdaily.com/http_ / 31 / content_ HTM? Div = - 1 German scientists who plundered the achievements of Chinese scholars are suspected of academic misconduct The Committee of Heidelberg University recently announced that the investigation found that Christof Sohn, director of gynecology clinic of Heidelberg hospital, had "serious and large-scale academic misconduct" In addition, Yang Rongxi, a former colleague and Chinese scholar, was suspected of plagiarizing the research results The hospital, which has been mired in the scandal for weeks, is now in the process of criminal proceedings The hospital had planned to release an external investigation result in a press conference on October 22 - the same day as the report of the academic integrity Committee of Heidelberg University However, on the same day, the local court approved Sohn's request and ordered the cancellation of the press conference to protect Sohn's rights and maintain the presumption of innocence Sohn is said to have been suspended for three months and face disciplinary investigations at the school After the court order was issued, the University also removed the Commission report from the website http://news.sciencenet.cn/htmlnews/2019/10/432128.shtm