[quick news] October 10, 2017 Tuesday

The team of Tal Danino from the Department of Biomedical Engineering, Columbia University, United States, and several research institutions have proved that bacteria in pancreatic tumors (intratumoral bacteria) can degrade the effect of gemcitabine, a commonly used chemotherapy drug The researchers first found that gemcitabine (2,2-difluoro-deoxycytidine) was 2,2-difluoro-deoxyuridine (2,2-difluoro-deoxycytidine) metabolized by bacteria in colon cancer model This metabolism mainly depended on a long-acting cytosine deaminase (CDDL) expressed by bacteria, which was initially found in gamma proteobacteria In colon cancer model, γ - protein bacteria expressed CDDL to resist gemcitabine The drug resistance effect disappeared after the combination of ciprofloxacin Because gemcitabine is the most common chemotherapy drug for pancreatic ductal adenocarcinoma (PDAC), the researchers speculate that the bacteria in the tumor may also help pancreatic cancer develop drug resistance After verification, they reached the same conclusion From computational simulation to experimental verification, to test the cancer tissues of 113 human PDAC patients The researchers found that 86 (76%) of the patients were positive for bacteria, mainly γ - protein bacteria This preclinical study provides an attractive strategy for the treatment of pancreatic cancer Science http://science.sciencemag.org/content/357/6356/1156.long enterprises want to turn manure into fertilizer fuel and profit from it Since 2015, there has been a facility called pivot in nduba landfill, a suburb of Kigali, the capital of Rwanda There are staff in green one-piece suits who are ready to treat fecal sludge into dry powdered fuel in a row of sheds and a greenhouse with plastic roof Pivot was created by Ashley Muspratt, an environmental sanitation engineer Pivot sells fuel to cement and brick factories Key customers are usually international enterprises that regard fecal sludge as a renewable energy source and use it to replace coal Pivot provides safe evacuation services to settlements and plans to start grinding and blending other types of combustible waste with fuel Like IWMI, pivot also plans to expand in Africa and India In these places, millions of people used to defecate outdoors Now, thanks to the government's action plan, they are building toilets Their ultimate goal is to become the lowest cost supplier of municipal fecal sludge treatment Nature http:// protein injection or prevention of chemotherapy alopecia and hair loss is one of the most terrible side effects of chemotherapy A study of women with breast cancer found that about 8% of patients considered refusing treatment in order to save their hair Sung Jan Lin and colleagues from the National Taiwan University found that p53 blocked the activity of a hair growth promoting protein called Wnt3a This gives them an idea: if Wnt3a is injected directly into the scalp during chemotherapy, can it prevent hair from falling off? To test the idea, they injected mice with a commonly used chemotherapy drug Subsequently, the researchers injected water droplets with Wnt3a under the mouse epidermis Tiny blobs of water marked blue helped keep Wnt3a in a small area, allowing the team to study its impact As expected, the area infused with Wnt3a water droplets was still covered with thick fur five days after the mice received chemotherapy Instead, the area injected with untreated water droplets has become bald When the researchers analyzed the skin under a microscope, they found that protein therapy doubled the number of stem cells in the hair follicle base on the first day of injection in mice, which led to more hair growth Newscientist https:// Japanese researchers found that the new technology can mass produce heart "band aid" Japanese researchers have invented a new technology to use human induced pluripotent stem cells to mass culture cardiomyocytes This kind of artificial induced cardiomyocytes can help repair the damaged heart just like "band aid", which is expected to be used in the treatment of heart disease in the future Induced pluripotent stem cells (iPS cells) are stem cells derived from "reprogramming" mature cells, which have similar differentiation potential to embryonic stem cells Researchers at Keio University in Japan recently announced that they have improved their experimental methods by stacking 30 cm and 20 cm long and 20 cm wide induced pluripotent stem cell culture dishes into 10 layers to form a special multi-layer culture device, and invented a ventilation system to deliver oxygen and carbon dioxide evenly to them, and successfully cultured about 1 billion cardiomyocytes at a time Xinhua News Agency: http://news.xinhuanet.com/tech/2017-10/08/c_.htm "China University innovation capability monitoring report 2016" is published According to the report 2016 on the monitoring of the innovation ability of Chinese universities issued by the Ministry of science and technology on September 9, under the guidance and promotion of national policies, China's universities have changed from scale expansion to connotation development, and the comprehensive strength of scientific and technological innovation has been rapidly improved, especially in the construction of innovation ability, the cultivation of innovative talents, the output and transformation of scientific and technological achievements According to the latest statistics, by 2015, the full-time equivalent of R & D personnel in Chinese universities was 355000 person years, an increase of 46.7% over 2006, ranking first in the world The internal expenditure of R & D funds in Colleges and universities keeps increasing, reaching 99.86 billion yuan in 2015, 3.6 times of that in 2006 In 2015, the total amount of horizontal scientific research funds obtained by universities exceeded 35 billion yuan, and the direct trading volume of scientific and technological achievements exceeded 2 billion yuan Patent applications and licensing are growing rapidly The number of patents authorized by institutions of higher learning is 136000, including 57000 invention patents, more than one fifth of the national total, 9.2 times that of ten years ago Based on the statistical data of national universities from 2005 to 2014, combined with the national innovation survey data in 2015, the report 2016 selects 78 indicators from five aspects: university innovation, innovative talent training, research and development activities, transformation of scientific and technological achievements and cooperation between industry, University and research, and analyzes the overall situation and basic characteristics of innovation ability of national universities Monitoring Xinhua News Agency http://news.xinhuanet.com/2017-10/09/c_.htm