[quick news] on October 17, 2019, why do people tend to get fat in middle age, or it is related to lipid turnover in adipose tissue

Why is it easy to get fat in middle age, or is it related to lipid turnover in adipose tissue? An international research team recently published a paper in the British journal Nature Medicine, saying that this may be related to lipid turnover (the ability to store and remove lipids) in fat tissue As people grow older, they are more likely to gain weight even if they don't eat more and exercise less The researchers said they followed the fat cells of 54 adult men and women for an average of 13 years The results showed that the ability of lipid turnover in adipose tissue decreased in all subjects regardless of weight gain or loss Those who didn't make up for it by cutting calories gained an average of 20 percent The study also found that in addition to those who "hedge" the decline in lipid turnover by reducing calorie intake, the rest of the subjects gained an average of 20% in weight The researchers believe that lipid turnover in adipose tissue is an important factor in weight regulation The results are expected to open up a new way for the treatment of obesity Http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2019-10 / 14 / content_ HTM? Div = - 1 The statistical announcement on the implementation of national education funds in 2018 was released by the Ministry of education, the National Bureau of statistics and the Ministry of finance According to the announcement, the total investment in education in 2018 was 4614.3 billion yuan, an increase of 8.41% over the previous year's 4256.201 billion yuan The national financial education expenditure was 3699.577 billion yuan, an increase of 8.15% over the previous year's 3420.775 billion yuan, accounting for 4.11% of GDP This is the first time that more than 4% has been achieved in 2012, which has remained above 4% for seven consecutive years, and 4% of the achievements have been further consolidated The national general public budget education expenditure was 3199.273 billion yuan, an increase of 6.93% over the previous year's 299.1978 billion yuan; the proportion of the national general public budget education expenditure in the general public budget expenditure was 22090.413 billion yuan, 14.48%, 0.25 percentage points lower than the previous year's 14.73% Http://www.moe.gov.cn/jyb/xwfb/gzdt/gzdt/s5987/201910/t2019016/u403829.html the degradation rate of polystyrene by sunlight is much faster than scientists expected A study by the Woods Hole Institute of Oceanography in the United States shows that polystyrene may degrade in decades to hundreds of years after exposure to sunlight, rather than being able to last for thousands of years in the environment as previously thought by scientists To test whether polystyrene can survive for thousands of years or even forever, researchers at the Woods Hole Oceanography Institute conducted a special experiment They put five commercially available polystyrene samples in water and exposed them to simulated sunlight three times stronger than the equatorial sunlight The results showed that simulated sunlight partially oxidized all five samples into dissolved organic carbon The researchers calculated that in the natural environment of 0 ° - 50 ° north latitude, which extends from the equator to the southern border of Canada, it only takes decades to complete this part of oxidation process, while it takes hundreds of years to completely oxidize polystyrene to carbon dioxide That is to say, sunlight can partially or completely degrade polystyrene in decades to hundreds of years, much faster than previously thought Http://digitalpaper.stdaily.com/http'www.kjrb.com/kjrb/html/2019-10 / 14 / content HTM? Div = - 1 A new study by the Marc C Hochberg research group of the University of Maryland on the restoration of cartilage thickness by injecting a new arthritic drug sprifermin The effect of placebo and placebo on the thickness of femoral tibial articular cartilage in patients with osteoarthritis The study was published in the recently published journal of the American Medical Association A total of 474 (86.3%) participants completed a two-year follow-up After two years of treatment, the total thickness of the femoral tibial joint cartilage in the 100 μ g sprifermin group increased 0.05 mm from baseline every 6 months, 0.04 mm from the 100 μ g sprifermin group every 12 months, 0.02 mm from the 30 mg sprifermin group every 6 months, and 30 μ g sprifermin from the 12 months, compared with the placebo group Group a increased by 0.01 mm The overall WOMAC scores of the four sprifermin treatment groups were not significantly improved compared with those of the placebo group The most common side effect was arthralgia, but there was no significant difference in the incidence between the groups Https://jamanetwork.com/journals/jama/article-abstract/2752470 rest protein is related to longevity According to a study published in nature, the activity level of brain neurons mediated by rest protein may have an impact on longevity The findings are based on a variety of studies in model organisms and humans, and may help researchers find new ways to delay human aging Past studies have shown that the nervous system is involved in the regulation of aging, but its basic mechanism has been difficult to clarify Bruce yankner of Harvard University Medical School in Boston and colleagues studied gene expression patterns in human brain after death, and found that genes related to nerve excitation and synaptic function were down regulated in long-lived individuals (at least 85 years old) In the study of online worms, they found that reducing the level of nerve excitation and synaptic activity in the brain of this model organism by drugs or genetic manipulation could prolong their life, while increasing the level of neuron activity would have the opposite effect This finding suggests that there is a causal link between life span and neuronal activity patterns https://www.nature.com/articles/s41586-019-1647-8