[quick news] on September 7, 2018, domestic innovative drugs for metastatic colorectal cancer were approved for marketing

Recently, domestic innovative drugs for metastatic colorectal cancer have been approved for market, and the State Drug Administration has approved the marketing of fuquitinib capsule (aiuite), a drug for the treatment of metastatic colorectal cancer Fuquinotinib capsule is an innovative drug that has not been listed at home and abroad, and has been approved to be listed through the priority review and approval process Furquitinib capsule is suitable for patients with metastatic colorectal cancer who have previously received fluorouracil, oxaliplatin and irinotecan based chemotherapy, and who have previously received or are not suitable for anti vascular endothelial growth factor (VEGF) treatment, anti epidermal growth factor receptor (EGFR) treatment (RAS wild type) Fiquitinib is a quinazoline type small molecule angiogenesis inhibitor, whose main target is VEGFR kinase family (VEGFR1, 2 and 3) By inhibiting the phosphorylation and downstream signal transduction of VEGFR on the surface of vascular endothelial cells, inhibiting the proliferation, migration and lumen formation of vascular endothelial cells, thus inhibiting the formation of tumor neovascularization, and finally playing the role of tumor growth inhibition Fuquinotinib capsule provides a new treatment for patients with metastatic colorectal cancer Http://cnda.cfda.gov.cn/ws04/cl2056/330121.html a scientific research team led by Professor Xiao Zhijian, Professor of Experimental Hematology State Key Laboratory of Hematology Hospital of Chinese Academy of Medical Sciences, Professor Huang Gang, Professor of special appointment of the laboratory and professor of oncology biologist of medical center of cinnati children's Hospital, USA Hypoxia inducible factor α (HIF1A) is a key molecule in the development of human myelodysplastic syndrome (MDS) The discovery was published online in the International Journal of cancer discovery Http://cancerdiscovery.aacrjournals.org/content/early/2018/08/22/2159-8290.cd-17-1203 latest research results show that sleep deprivation can make people lonely Lack of sleep can make people feel more lonely, less willing to socialize, and even the related brain neural pathways can change, according to a study published in nature communication The researchers integrated the international two brain image databases and analyzed the image behavior big data of nearly ten thousand subjects They found that the signal synchronization (function) of the lateral orbitofrontal cortex (brain function area related to negative emotions), cuneiform lobe (brain function area related to self) and dorsal prefrontal cortex (brain function area related to short-term memory) in the people with poor sleep quality At the same time, these neural circuits also showed a significant increase pattern in the population with higher depression scores It is these synchronic enhancements that modulate the relationship between depression and sleep The increased connectivity of these brain regions may cause the related population to be in some negative emotions for a long time, which may lead to the decline of sleep quality Https://www.nature.com/articles/s41467-018-05377-0 the remains of a foal 40000 years ago were found in the permafrost Researchers from South Korea and Russia are expected to clone and revive the ancient species They found a foal 40000 years ago in the permafrost of Siberian crater The muscle tissue of the foal is well preserved, and the black mane and tail, as well as a dark stripe along the spine, are clearly visible At present, researchers are in the process of cell collection If they can find living cells successfully, they will be able to clone and revive this species, and even lay a technical foundation for the goal of cloning mammoths Http://www.dailymail.co.uk/sciencetech/article-6133751/scientists-cell-samples-extinct-40-000-year-old-frozen-foel.html the supply is limited and the crude drug market continues to run at a high level Under the supervision of the central environmental protection group, "looking back" and the expectation of production cut-off in heating season, the market of raw materials and intermediates has been affected by the continuous rectification and off-season maintenance of chemical industry parks and enterprises, with no significant improvement in operating rate and low market volume The start-up of replenishment of upstream and downstream raw materials is under the pressure of low operating rate, and the supply continues to be limited The overall raw material market continues to run at a high level, and the wait-and-see mood of all parties in the industrial chain is strong, and the upstream and downstream games are in progress http://nongyao.jinnong.cn/n/2018/09/04/4608235072.shtml