[quick news] Thursday, January 18, 2018

US scientists found that activation of the internal failure of cancer cells can reduce the supply of nutrition, inhibit the growth of cancer cells, and not damage normal cells This method has been successful in animal experiments In healthy cells, two proteins, Rev Erb α and rev Erb β, are the core components of cell internal clock, which can carry out active fat synthesis and autophagy The contents of these two proteins are at high and low levels for half a day In cancer cells, two Rev-erb proteins do not work, fat synthesis and autophagy can be carried out endlessly Researchers use two kinds of activators for Rev-erb protein to activate the biological clock regulatory mechanism of cancer cells, so as to inhibit the growth of cancer cells Nature https://www.nature.com/articles/nature25170 South Korean Universities reached an agreement with Elsevier after months of standoff After months of standoff, an alliance of hundreds of South Korean Universities and Elsevier, a science publishing giant, reached a new agreement to obtain "science direct" Scientific guidelines is a database of 3500 academic journals and thousands of e-books The agreement, which includes a 3.5-3.9-percent increase in prices, was signed shortly before Elsevier threatened to cut off access to "scientific guidance" on January 12 Elsevier had asked for a 4.5% price increase Science https://www.sciencemag.org/news/2018/01/south-korean-universities-reach-agreement-elsevier-after-long-standoff the first car-t treatment new indications are qualified for priority review Recently, Novartis's application for approval of complementary biological agents (SBLA) for car-t therapy kymeriah (tisagenlecleucel) has been approved by the US FDA as a priority for the treatment of adult patients with relapsed or refractory (R / R) diffuse large B-cell lymphoma (DLBCL) These patients are not suitable for or relapse after autologous stem cell transplantation (ASCT) In addition, the European Drug Administration (EMA) has granted kymriah an accelerated evaluation of the application for marketing authorization (MAA) for the treatment of children and young patients with R / R B-cell acute lymphoblastic leukemia (all) and adults with R / R DLBCL who are not suitable for ASCT If approved, it will be the first car-t therapy that can be used for two different indications: non Hodgkin's lymphoma and B-cell all Bio space https://www.biospace.com/article/releases/novartis-kymriah-snags-speed-review-from-the-fda-ema/ earthjustice wants EPA to ban three types of pesticides According to the latest report of NOAA, chlorpyrifos, malathion and diazinon can harm endangered salmon and endanger their survival Earth justice, a non-profit environmental law organization, released the report, introducing that chlorpyrifos was widely used in orchards and malathion was used in more than 100 food crops, including alfalfa, cotton, rice and wheat "Diazinon" is used in fruit trees, rice, corn, sugarcane, potatoes and horticultural plants They asked the U.S Environmental Protection Agency (EPA) to ban the use of these chemicals in agricultural production Science www.sciencemag.org/news/2018/01/common-pesticides-threaten-salmon-us-fisheries-agency-includes single molecule effective charge has been detected for the first time many life phenomena involve the interaction between proteins and other molecules, in which the charge plays a crucial role However, proteins usually exist in aqueous environment, so it is difficult to accurately measure the charge of proteins in this environment by traditional methods Swiss scientists have found a way to accurately measure the charge of a single molecule in a solution This new discovery not only has important basic research value, but also helps to diagnose many diseases caused by abnormal proteins, such as Alzheimer's disease and cancer Phys.org https://phys.org/news/2018-01-precise-molecule-effective.html