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3) Gas chromatography-mass spectrometry detection derivatization
①Methylation (Figure 19-7)
Figure 19-7 Schematic diagram of methylation of thiouracil drugs
Yu et al.
② Fluorinated silanization
Le Bizec et al.
Figure 19-8 Schematic diagram of fluorination of thiouracil drugs
After adjusting to acidity (pH3) with glacial acetic acid, the -O-PFB derivative is hydrolyzed to -OH, while -S-PFB remains unchanged to generate mono-PFB derivative
Figure 19-9 Schematic diagram of silanization of thiouracil drugs
Liu et al.
Figure 19-10 Schematic diagram of MBI fluorination
Related links: thiouracil drug residue analysis technology-fluorescence detection derivatization
