Tranquilizer metabolism and toxicology

13.

13.

(1) Barbiturates

Barbiturates are mostly metabolized in the liver.

(2) Benzodiazepines

Benzodiazepines are degraded in the liver and metabolized by deethylation, hydrolysis or other pathways to produce active metabolites, which are slowly eliminated

Diazepam is quickly and completely absorbed orally, with a bioavailability of about 70%

(3) Phenothiazines

The metabolism of phenothiazine drugs in the body is very complicated, with at least more than 10 products, and the main metabolic pathway is oxidation

(4) Butyrylbenzenes

Haloperidol is well absorbed orally.

13.

(1) Barbiturates

Barbiturates act on the central nervous system, and their applications range from mild sedation to complete anesthesia.

(2) Benzodiazepines

Benzodiazepines can cause adverse reactions such as dizziness, drowsiness, fatigue, and fine motor incoordination.

(3) Phenothiazines

Overdose of chlorpromazine can cause ataxia, coma, behavior changes, irregular body temperature changes, disorder of sex hormones and hypothalamic stimulating hormone release, increased appetite, hypotension, and tachycardia

Acepromazine excess causes rigidity, tremor, excitement, and low blood pressure

The common side effects of xylazine in most animals are increased saliva secretion, sweating in horses, occasional seizures and central excitement

(4) Butyrylbenzenes

Butyrophenones are relatively less toxic, have short-lived effects, and can cause hypotension

Related links: Uses of tranquilizers