Unlock micro-reverse synthesis of bulk chemicals for high throughput and low investment

Microchannel and microreactor technology is an efficient and safe disruptive technology, which is called the future technological revolution and industrial transformation by the industry, but low production capacity, high cost, poor versatility and low cost performance are the normal feelings of users
.
The following introduces a professional microreactor technology company.
Its unique design can meet the needs of fast and medium-speed chemical synthesis of different scales of chemical enterprises.
Invest in the synthesis of bulk chemicals with fast return" and "no amplification effect"
.

In 2021 and the first half of 2022, Zhongshan Zhi'an Chemical Technology Co.
, Ltd.
(hereinafter referred to as Zhongshan Micro-Reaction) attaches great importance to strengthening strategic scientific and technological strength, and continuously increases investment in research and development.
It has been put into operation in large and medium-sized enterprises such as Jiangsu Yangnong Chemical Co.
, Ltd.
, Xinfa Pharmaceutical Co.
, Ltd.
, and Zhuhai Free Trade Zone Livzon Synthetic Pharmaceutical Co.
,
Ltd.
At present, it has been successfully applied to reaction types such as oxidation, condensation, cyclization, and nitrification.
Among them, Jiangsu Yangnong Chemical Co.
, Ltd.
is a famous pesticide manufacturer in China and a "green factory" demonstration unit.
Its nitrification microreactor is used in pesticide production.
, the flux exceeds 20000m³ / a
.
The production capacity of the cyclization microreactor operated by Xinfa Pharmaceutical Co.
, Ltd.
is also close to 10,000 tons/set, and all data indicators are significantly better than imported microreactors
.

Zhongshan Micro Reactor is committed to replacing traditional chemical synthesis equipment such as reactors, fixed beds, and tubular reactors
.
It breaks through the shortcomings of traditional micro-reactors, breaks the impression of chemical companies on the high cost and low practicability of micro-reactors, and helps enterprises to produce safely, increase production capacity, and save energy and reduce emissions
.
Zhongshan Micro Reactor has successfully developed a 3D printing microreactor and a silicon carbide microreactor.
The case application results show that its yield, conversion rate and benefit are higher than other synthesis equipment, and the three wastes and energy consumption are far lower than other synthesis equipment
.
In terms of long-term use, the cost of the micro-reaction technology and the costs incurred later are far lower than the cost of traditional chemical equipment
.

Question 1: Microchannel and microreactor continuous flow equipment has high investment cost and few application types.
How can it generate benefits for chemical synthesis enterprises?

The first is a technological breakthrough.
Zhongshan Micro-Reaction uses 3D printing technology to manufacture micro-channel reactors, which solves the embarrassing situation of micro-reactors with “structured design but no industrialized products”.
Coupled with the maturity of silicon carbide processing technology, the manufacturing cost has dropped to 100,000 to 300,000 yuan/liter of liquid holding capacity
.

Take the liquid holding capacity of 6L as an example and the production capacity of 10000m³/a as an example:

1.
The cost of the microreactor is 900,000 yuan;

2 The cost of the special pump for micro-reverse is 250,000 yuan;

3.
Zhejiang Zhongkong one-key automatic control system 300,000 yuan;

4.
The total budget is 2-3 million yuan
.

A set of microreactors can replace 10~20m³ reactors.
Although the investment cost is slightly higher than the comprehensive investment cost of traditional equipment, the overall cost of site occupation, auxiliary equipment, energy consumption, consumables, three wastes, manpower and other comprehensive costs are greatly increased.
In the long run, the cost of microreactors is much lower than that of traditional equipment
.

Question 2: Which cases have significant benefits?

The chemical industry has always been in an environment of standardization improvement.
There are only a few cases of successful small-scale and pilot-scale microreactors, based on various reasons, for simultaneous industrialization and amplification
.
Taking Livzon Synthetic Pharmaceutical Co.
, Ltd.
in Zhuhai Free Trade Zone as an example, the traditional reaction kettle is used for oxidation reaction.
The products and raw materials are unstable in the system, and the yield and yield fluctuate greatly.
Some batches of products are difficult to handle.
After the industrialized microreactor was produced, the product yields all reached the target, saving over 10 million yuan of raw material consumption every year; a nitrification reaction in Jiangsu Yangnong Chemical Co.
, Ltd.
released a lot of heat, and the Zhongshan microreaction reactor was used to easily solve the problem of production capacity , to achieve intrinsic safety; after Xinfa Pharmaceutical Co.
, Ltd.
adopted 10,000-ton flux micro-reaction, the cost and production efficiency were significantly improved, and the technical transformation from the traditional process of upstream and downstream raw materials to micro-reaction process has been started
.

20000m³ /year pesticide intermediate synthesis
microreactor

Price comparison between microreactor and traditional reactor

Question 3: What is the maximum capacity of a single set of microreactors in your company?

Zhongshan Micro Reactor adheres to the concept of "technological innovation is the life of an enterprise, and provides valuable technical services", and has successfully developed 3D printing microreactors
.
The cross section of the SiC microreactor can reach 300~500mm², and the theoretical flux can achieve a production capacity of 20000~30000m³/set
.

3D printed high-pressure corrosion-resistant microreactor  

High Throughput Silicon Carbide Microreactor

Question 4: What is special about your microreactor technology?

In general, the domestic microreactor technology is constantly iteratively updated.
The technical differences of Zhongshan's micro-reverse micro-channel are reflected in five aspects: 1.
The inner and outer jacket structure solves the problem of heat exchange efficiency; 2.
Micro flow channel, high cross-sectional area, low pressure The downflow channel can solve the problem of mass transfer; 3.
The equipment can meet the process requirements, meet the requirements of fast, medium and fast response, and the residence time can reach 20 minutes; ; Five, mature process configuration experience, high configuration to maintain the advanced nature of the equipment
.

Question 5: What chemical systems are suitable for the continuous flow of microreactors?

Microreactors have significant effects on the following systems:

1.
High viscosity system;

2.
fast response system;

3.
Heterogeneous systems;

4.
temperature sensitive system;

In addition, more meaningful usage scenarios include medium-speed reactions of 50~500J/mL , such as condensation, esterification, aminolysis, addition, polymerization, decarboxylation and other types of reactions with long dropping time and large production capacity.
Exothermic and corrosive scenarios where the reactor is incapable
.
At the same time, for some reactions (oxidation reaction, condensation reaction, addition reaction.
.
.
), the residence time takes 3 to 10 minutes, and a better expected effect can be achieved in the microreactor
.

Whether the micro-reaction process is successful or not is mainly evaluated in four aspects: 1.
Whether stable and accurate feeding can be achieved; 2.
A stable flow field can achieve good mass transfer effect; 3.
Heat exchange capacity and flux matching; 4.
Microreactor structure Can adapt to the reaction mechanism
.

Question 6: What is the company's current plan for the current micro-reverse business direction?

Forward-looking chemical synthesis technology is inseparable from the adaptability of raw materials, process methods and equipment
.
Zhongshan Micro-Reverse's micro-reverse equipment and technical services, in line with the goal of achieving easy synthesis and generating benefits for customers, completes small-scale process screening and pilot-scale process verification for customers
.
In addition, the directional development of the micro-reverse process of the new synthetic process route is also under preparation
.