Use of non-steroidal anabolic hormone drugs

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2 Purpose

Non-steroidal anabolic hormones mainly bind to the ligand binding domain of estrogen receptors (ER), which can cause the configuration of ER to change, and the complex formed moves to the nucleus and binds to the DNA template.
Thereby regulating target gene transcription and protein synthesis
.

Non-steroidal anabolic hormones and steroidal anabolic hormones have similar anabolic activities, mainly as follows: assimilation metabolism; increased muscle/fat ratio; increase basic metabolism, improve feed conversion rate; inhibit the effect of alienation metabolism, reduce material consumption; stimulate erythrocytes The production of hormones, or directly act on the bone marrow hematopoietic system to increase red blood cell production; androgen , estrogen and glucocorticoid receptors have been found in skeletal muscle cells , indicating that steroidal anabolic hormones may directly act on muscle cells to cause muscle proliferation

Figure 9-1 Transformation relationship of RALs

DES and other stilbene non-steroidal anabolic hormones are currently clinically mainly used to treat various diseases caused by ovarian insufficiency or pituitary dysfunction, amenorrhea, uterine hypoplasia, functional uterine bleeding, menopausal syndrome, and senile vaginitis and back milk and so on
.

In addition, DES is also used as an anti-lactation drug for women who do not choose to breastfeed after childbirth, or as a female oral contraceptive, and can also be used to treat breast and prostate cancer

ZER is an ideal skin weighting agent.
Its mechanism of action is generally believed to directly or indirectly act on the pituitary gland and pancreas to increase the level of growth hormone and insulin in the body, promote the synthesis of animal body protein, and improve feed Utilization rate, which has the effect of promoting weight gain
.

ZOL and ZON also have estrogenic activity

Related Links: Physical and Chemical Properties of Non-steroidal Anabolic Hormone Drugs