What is fibrin?

Fibrin is a very important protein, which is the key element in the final stage of coagulation to stop bleeding It is insoluble and produces connective tissue at the wound site, which stops bleeding by hardening It is produced by the body only when it is needed In case of injury, the human body will send signals to produce fibrin The difficulty or lack of this protein can lead to life-threatening diseases This protein is produced by a process called polymerization, in which small molecules called monomers bind together When the human body is traumatized, it releases thrombin, which signals the body to produce a soluble protein called fibrinogen The two substances combine in the wound to produce fibrin, which coagulates the blood In addition to coagulation, fibrin also plays a role in activation of platelets, signal transduction and protein polymerization Without fibrin to complete the clotting process, patients will experience major bleeding or hemophilia Hemophilia includes clotting disorders, and major bleeding occurs when the blood loses a quarter Too much fibrin can also be dangerous, as it can lead to thromboembolism, the formation of blood clots in blood vessels No matter thromboembolism or hemophilia, non treatment will lead to death Fibrinogen hemopathy is a liver disease associated with decreased or abnormal production of fibrin, both of which are very dangerous Patients tend to have major bleeding and are usually treated with enzyme replacement therapy to produce protein molecules Other treatments include transfusions of plasma or drugs that help clot The abnormality of blood fibrin can also be caused by genetic diseases, such as hypofibrinogenemia and abnormal fibrinogenemia These diseases lead to the disorder of protein production and blood diseases Some medical products have a protein like effect For example, fibrin glue is an artificial substance produced by thrombin and fibrinogen, which has the function of skin adhesive This gel is most often used in surgery, reducing healing time, plugging or covering holes and suturing wounds The human body also produces fibrin scaffolds, which are naturally generated after injury Doctors can manipulate these scaffolds to rebuild tissue They are very useful for repairing the damage of nervous and cardiovascular system.