Yuan Daqiang research group of Fujian Institute of physical composition, Chinese Academy of Sciences has made important progress in the study of unit point catalysis of MOFs materials

Metal organic framework materials (MOFs) are a kind of new crystalline porous materials with clear pore structure and adjustable pore diameter formed by coordination and self-assembly of metal clusters / ions and ligands They have been widely used in catalysis, bionics, fluorescence, chemical sensing, gas adsorption and separation, etc At the same time, MOFs materials have high specific surface area and adjustable internal microenvironment, which can make the catalytic active sites uniformly disperse and enrich the reaction substrate, so it can be used as an excellent unit point catalyst platform Indoles have high application value in the field of biomedicine, but in the past, most of the catalysts used to catalyze intramolecular amination of indoles involve precious metal materials, such as gold, silver, platinum and so on In order to reduce the cost of catalyst and get indoles more efficiently and economically With the support of the strategic leading science and technology program of the Chinese Academy of Sciences and the National Natural Science Foundation of China, Yuan Daqiang, the research group of Fujian Institute of material structure and the State Key Laboratory of structural chemistry of the Chinese Academy of Sciences, synthesized a unit point zinc ion catalyst based on MOFs by post modification method, which was used to catalyze the intramolecular hydrogen amination of o-alkynylaniline compounds By means of scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy, the author characterized the catalyst after use, and confirmed that the morphology and zinc active site of the catalyst after use had not changed The zinc catalyst of MOFs unit point has the advantages of high efficiency, stability, easy recovery and recycling in the process of catalytic intramolecular hydrogen amination, and the reaction system does not need to add ligands, alkali or acid, and the reaction conditions are clean and mild Under similar homogeneous catalysis conditions, the hydrolysis products of o-alkynylaniline are mainly obtained, which shows that the unique internal microenvironment provided by MOFs can affect the main direction of catalytic reaction, so as to obtain different main products The existence of isolated metal sites in MOFs not only improves the catalytic efficiency, but also makes the catalytic sites more obvious, which is more helpful to explore the reaction mechanism This work shows that MOFs can be used as a high efficient and recyclable unit point catalyst material and used in the synthesis of fine chemicals The above results were published on angelw Chem Int ed (DOI: 10.1002 / anie 201902171) The first author of the paper was Li Beibei, a doctoral candidate This achievement is the latest progress in heterogeneous catalysis of MOFs materials by Yuan Daqiang, a researcher of Fujian Institute of physical composition Previous research achievements include the Friedel Crafts reaction catalyzed by MOF based hydrogen bond catalytic sites (chem Mater 2016, 28, 2000-2010); ring opening reaction of phenyloxirane catalyzed by MOF based br ø nsted Acid site (chem Commun 2016, 52, 13671-13674); carbonation of CO 2 in flue gas catalyzed by MOF based br ø nsted Acid site (NAT Commun 2017, 8, 1233); Mannich reaction catalyzed by MOF based photocatalyst (appl Catalyst B 2018, 221, 664-669) ）Reaction with cross dehydrogenation coupling (appl Catalyst B 2018, 227, 425; J am Chem SOC 2019, 141, 3129-3136)