Zhejiang University invents a new type of chemical microscope, the results are on the cover of "Nature"

Zhejiang University announced on August 12 that Feng Jiandong's research team in the Department of Chemistry at the university has invented a microscope technology that can directly image single-molecule chemical reactions in solution, and has achieved ultra-high space-time resolution imaging
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This technology has important application value in the fields of chemical imaging and biological imaging, allowing clearer microstructure and cell images to be seen

Traditional chemistry and biology study reactions and changes involving a large number of molecules
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Observing, manipulating, and measuring the most microscopic single-molecule chemical reactions is a long-term scientific challenge facing scientists

On August 11, Beijing time, this research result was published as a cover paper in the top international journal Nature
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The first author of the thesis is Dong Jinrun, a doctoral student in the Department of Chemistry, Zhejiang University, and Lu Yuxian, a postdoctoral fellow; the corresponding author of the thesis is a researcher Feng Jiandong, the Department of Chemistry, Zhejiang University

The research object of the Zhejiang University team is electrochemiluminescence reaction
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Electrochemiluminescence is a form of using a series of chemical reactions that occur on the surface of an electrode to achieve luminescence

Over the past 3 years, Feng Jiandong’s team has been dedicated to the study of these two major problems.
By combining a self-made electrochemical measurement system with picoamp level current detection capability and a wide-field super-resolution optical microscope, a set of highly efficient electrochemiluminescence has been built.
Control, measurement and imaging system
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For the first time, the wide-field spatial imaging of single-molecule electrochemiluminescence signals was realized; and on this basis, the optical diffraction limit was successfully broken, and the super-resolution imaging of electrochemiluminescence was realized for the first time

In the future, this microscopy technology will be used as a research tool to provide new possibilities for the visualization of chemical reaction sites, single-molecule measurement, chemistry and biological imaging, and has a wide range of application prospects