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examples conformers

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Development of farnesol receptor agonist LJN452: application examples of conformational restriction strategies

 Time of Update: 2021-05-22

The compound has excellent performance in in vitro testing, but the PK data is too poor (high clearance and low bioavailability), as well as potential toxicity and light instability, mainly caused by the stilbene structure in the structure, which greatly limits the possibility of its preparation as a drug Therefore, the optimization of the stilbene structure has become the first breakthrough direction.

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