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Acta Neuropathologica: In-body amplification of pathogenic tau proteins retains disease-specific bioactive characteristics
Time of Update: 2021-02-26
recent studies have shown that tau strains exhibit strain-specific biological activity in tau propagation models, also known as pathogenicity.
, however, whether the specific pathogenicity of strains of tau seeds from primitive human sources can be maintained in amplified tau strains remains to be tested.
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Acta Neuropathologica: The accumulation of end fragments of amyloid preloom protein C triggers
Time of Update: 2020-10-30
collecting the liquid as the total fraction, the other part at 4 degrees C at 10000 × g centrifugation for 10 minutes to precipitate mitochondrial fractions, it suspended in a separation buffer with protease inhibitors added.
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Acta Neuropathologica: C9orf72 and non-C9orf72 ALS and TLD-TDP cases along the hemline-pituitary
Time of Update: 2020-10-29
dipeptide repetition protein (DPR) derived from the repeated amplification of C9orf72 in neurons represents another neuropathological feature in patients with C9orf72 ALS and FLD-TDP.
Dipeptide protein repeat and TDP-43 pathology along the hypothalamic-pituitary axis in C9orf72 and non-C9orf72 ALS and FTLD-TDP cases.
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Acta Neuropathologica: Insulin-like growth factor 2 (IGF2) prevents Huntington's disease by treating protein aggregates outside the cell.
Time of Update: 2020-10-17
the team of authors has previously reported on the target transcription factor XBP1, a key medium for endoensurgen stress response, which slows disease progression and reduces protein aggregation in various neurodegenerative variant models.
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Acta Neuropathologica: Blue spot degeneration is a common feature of tau disease, unlike TDP-43
Time of Update: 2020-10-17
, we have validated the hypothesis that FTLD-TAU's LC neuropathology and neurodegenerative changes are significant compared to FLD-TDP.
the pathological and clinical subgroups of FTLD-TDP, the tau load and neurodegenerative changes of LC continued to increase compared to the FLD-TDP subgroup.
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Acta Neuropathologica: Different clinical pathology groupings for patients with TDP-43 protein disease.
Time of Update: 2020-09-25
Although many brains have different pathological states, the authors found four identifiable clusters, the main identification of which was neuropathological changes (ADNC) in age of death and the severity of Alzheimer's disease, especially neurosomalloid plaque density.
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Clinica Chimica Acta: Serum secretes acidic proteins and is rich in cysteine-like protein 1 as a prognosis indicator for severe brain injury
Time of Update: 2020-06-22
Prior studies have shown that the secretion of acidic proteins - rich in cysteine-like protein 1 (SPARCL1) increases synaptic stability through axon regeneration The purpose of this study was to d
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Clinica Chimica Acta: Study on the ratio of albumin to fibrinogen, c-reactive protein and albumin
Time of Update: 2020-05-29
Albumin-fibroprotein-in-figen ratio (AFR) and c reactive protein-to-albumin ratio (CAR) are often used as markers of inflammation However, their role in RA remains unclear We studied the rela
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What is the diagnostic value of Clinica Chimica Acta: 14-3-3 thain and anti-carbide protein antibodies in northern Han rheumatoid arthritis?
Time of Update: 2020-05-29
Rheumatoid arthritis (RA) cannot be ruled out when rheumatoid factor (RF) or anticyclic gualine peptide antibody (anti-ccp) is negative Here, we identified the application value of 14-3-3 proteins,
