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    proton leak

    Echemi shares information about proton leak. Our coverage of proton leak news, knowledge and opinion is widely.
    • Measurement of Mitochondrial Membrane Potential and Proton Leak

      Time of Update: 2021-01-02
      Dissipation of the mitochondrial membrane potential causes uncoupling of the electron transport through the respiratory chain and the phosphorylation reaction for ATP synthesis (proton leak). Proton leak functions as a regulator of mitochondrial reactive oxygen species (ROS) production and its modulation by uncoupling proteins, which may be involved in pathophysiology.
    • Measurement of Proton Leak and Electron Leak in Isolated Mitochondria

      Time of Update: 2020-12-09
      Oxidative phosphorylation is an important energy-conserving mechanism coupling mitochondrial electron transfer to ATP synthesis. Coupling between respiration and phosphorylation is not fully efficient due to proton and electron leaks. The relative strength of a modular kinetic approach to probe oxidative phosphorylation is emphasised.

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