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Trends in Plant Science: A high-throughput screening strategy for non-toxic genes of multi-pile
Time of Update: 2023-02-03
High-throughput screening strategies for non-toxic genes and maize disease resistance genes in multi-pile rust bacteria The southern rust of maize caused by the infestation of Puccinia polysora underw is widely epidemic in the world, which seriously threatens the safe production of maize in China and the world, and sustainable control of maize southern rust urgently needs reasonable and effective cultivation and planting of resistant varieties.
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The "Ammonia-resistant Penaeus monodon germline screening method" of the South China Sea Institute
Time of Update: 2022-09-05
A few days ago, the "Ammonia-resistant Penaeus monodon germline screening method" invented by Jiang Song, Jiang Shigui, Zhou Falin and others from the South China Sea Fisheries Research Institute of the Chinese Academy of Fishery Sciences has obtained the national invention patent authorization, the patent number is ZL201711458267.
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Genome-wide screening identifies novel targets for the treatment of sorafenib-resistant hepatocellular carcinoma
Time of Update: 2022-05-18
Interestingly, this study found that FGF21 positively regulates the expression of Nrf2 both in vitro and in vivo .
FGF21 exerts a function-enhancing role in the KEAP1-Nrf2 pathway, enabling hepatoma cells to acquire sorafenib resistance .
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Zhang Feng's new paper: CRISPR activation screening to discover key proteins of cancer immunotherapy resistance
Time of Update: 2022-04-23
The study found that BCL-2 and B3GNT2 are key drivers of cancer cell resistance to cytotoxic T cells through CRISPRa Screen, and inhibition of these two proteins can enhance the sensitivity of tumor tissue to immunotherapyThis result suggests that a CRISPR-activated screening system can help to elucidate resistance pathways and identify potential targets for cancer immunotherapy .
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A screen to identify drug resistant variants to target-directed anti-cancer agents
Time of Update: 2021-03-04
Defining the spectrum of such mutations is important for patient monitoring and the design of next-generation inhibitors.
Using imatinib and BCR/ABL as a paradigm for a drug-target pair, we recently reported a retroviral vector-based screening strategy to identify the spectrum of resistance-conferring mutations.
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Screening Arabidopsis Genotypes for Drought Stress Resistance
Time of Update: 2021-01-16
A high throughput drought screen is described forArabidopsis that is based on a gravimetric method to monitor and control water content of the soil.
To screen for plant growth under mild drought conditions, 30% of field capacity can be used, which is equal to 2 g H 2 O/g dry soil.
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Herbicide Resistance Screening Assay
Time of Update: 2020-11-07
Herbicide resistance screening is a method that can be used not only to determine presence of the enzyme, phosphinothricin acetyltransferase, encoded by either theBar or thePat gene in transgenic maize, but also to assess the inheritance ratio of those genes in a segregating population.
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Br J Cancer: CRISPR/Cas9 Genome-wide Functional Loss Screening Technology identifies
Time of Update: 2020-10-12
study aims to identify cytokines that affect schoinib resistance using CRISPR/Cas9-based high-volume loss of function (LOF) screening techniques.
, the results show that CRISPR/Cas9 LOF screening technology is a promising method that can be used to identify and target cytokines associated with resistance to anti-cancer drugs.
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TB bacteria screening marker gene: dif-hsp60-aacC1-tsr-dif resistance expression box.
Time of Update: 2020-09-09
Every year, 24 March is World Tuberculosis Day, and this year's theme is "Society Working Together to Eliminate the Harm of TB". TB, known as rickets, continues to make a comeback with the drug "hide