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Cutting-edge advances| the results of a single-arm phase II study on the application of the TGF-β
Time of Update: 2022-10-13
Based on this, a Phase II single-arm study evaluated the efficacy and safety of galunisertib combined with neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer, and the results were published in Lancet Oncology (IF:54.
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Scientists invent 'cancer environmental immunotherapy' β targeting TGF-Sera
Time of Update: 2021-02-25
On October 21st, local time, the team of immunologists at memorial Sloan Kettering Memorial Cancer Center in the United States published two "back-to-back" articles, "TGF-β suppresses type 2 immunity to cancer" and "Cancer immunotherapy via targeted TF-β signalling in TH cells".
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Dual-functional immunotherapy! The FDA awarded Merck TGF-β/PD-L1 dual-target therapy M7824 to treat bile duct cancer orphans.
Time of Update: 2021-02-12
BTC treatment options are limited, the medium survival of late-stage patients is less than 1 year, the objective tumor mitigation rate for common chemotherapy is usually less than 10%, and the remission time is short.
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Br J Cancer: TNIK inhibitor NCB-0846 blocks the TGF beta/SMAD signaling path path to inhibit the metastasis of lung cancer
Time of Update: 2020-12-16
study explores the effects of NCB-0846 on the EMT process of lung cancer induced by TGF beta1.
NCB-0846 inhibits the metastasis of lung cancer cells Researchers have found that NCB-0846 inhibits the EMT process of TGF beta-induced A549 cells.
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Nature breakthrough! Targeting TGF-β "cancer environmental immunotherapy" or a new dawn against cancer.
Time of Update: 2020-10-30
, on October 21st, the team of immunologists at the Memorial Sloan Caitlin Memorial Cancer Center in the United States published two "back-to-back" articles, "TGF-β suppresses type 2 immunity to cancer" and "Cancer immunotherapy targeted via TGF-β signalling in TH cells." these two articles, one is a basic study and the other is a translational study that offers new hope for the fight against cancer in humans.
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What anti-cancer therapies are being developed by TGF-beta scientists in the face of cancer "rebels"?
Time of Update: 2020-09-30
in the early stages of tumor development, TGF-beta plays the role of an anti-cancer "military division." TGF-beta's tumor suppression is derived from its ability to induce multiple gene expressions that are involved in inhibiting cell proliferation, inducing apoptosis, activating autophagy, inhibiting growth factor signals through substrate fibroblasts, inhibiting inflammation, and inhibiting angiogenesy.
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Adv Sci: Reveals the important role of TGF beta 2 in esophageal cancer metastasis and targeted intervention strategies.
Time of Update: 2020-08-04
Tumor metastasis is one of the top ten characteristics of cancer, and more than 90% of cancer deaths are closely related to tumor metastasis. More and more studies point out that the tumor microenvir
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Science Sub-journal: "Twin Killer" - TGF-beta - walking at both ends of cancer's "positive evil"
Time of Update: 2020-07-23
the results showed that TGF - β secreted by tumor can not only damage the metabolism and mitochondrial activity of CD4 T cells, but also produce a key anti-tumor molecule, IFN - γ, which is related to the phosphorylation of Smad Protein (which plays a key role in the process of transferring TGF - β signal from cell surface receptor to nucleus), but not to nuclear translocation.
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Adv Sci . . . The collaboration between He Qingyu/Li Bin/Xu Wei reveals the important role of TGF
Time of Update: 2020-07-17
recently, Professor He Qingyu, researcher Li Bin and associate researcher Xu Wenwen, Key Laboratory of tumor molecular biology, Ministry of education of Jinan University, published the title "direct targeting of CREB1 with imperatorin inhibitors TGF β 2-erk signaling to suppress esophageal cancer" In this paper, we analyzed the expression of TGF β 2 in clinical samples based on public database and clinicopathological data.
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NAT COMMUN: TGF-beta signal promotes the production of IL-22, which promotes the production of colon cancer
Time of Update: 2020-05-29
IL-22 has dual function in the tumor In the short term, il-22 is produced to protect cells from genetically toxic stress, while uncontrolled IL-22 promotes tumor growth; TGF-beta 1 promotes differ
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Cell: to reveal the mechanism of bone metastasis of prostate cancer through TGF - β resistance immunotherapy
Time of Update: 2019-11-20
November 20, 2019 / Biovalley BIOON / - -- in a new study, researchers from MD Anderson Cancer Center at the University of Texas reported that prostate cancer spreading to bone can cause bone tissue d