3D bioprinting builds a "live" map of artificial bone tissue.

Recently, the research team composed of Yan Changshun, researcher Pan Haobo and Professor Lu Weiga of the Center for The Decline of Human Tissueands and Organs of the Institute of Biomedicine and Technology of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences has made new progress in the field of artificial tissue manufacturing in 3D bioprinting.
research team to build a "living" artificial bone tissue that is precisely arranged into bone cells through bioprint optimization design and the development of induced bio-inks.
the "living" artificial bone manufactured, not only maintaintheon of the cell's short-term survival rate (more than 95% in 24 hours), but also enable the cell to function in and out of the body for a long time, and promote new bone regeneration.
related research in 3D-Bioprinted Osteoblast-Laden Nanocomposite Hydrogel Constructs with Research Byd Microenvironment S. Cell Viab, and Osteogenesis Both In Vitro and In Vivo, published in Advanced Science.
compounding adult cells or stem cells and biomaterials as bioprintinks, and the manufacture of functional artificial tissues and organs is a research hotspot and development trend of tissue restoration regeneration.
However, how to maintain the short-term activity of living cells after 3D printing and realize the long-term function of 3D printing artificial tissue in vivo and outside is the bottleneck that limits the research application of 3D biological manufacturing.
's Changshun research group engaged in 3D bioprinting and biomaterial ink-related research, has explored biomaterial degradation performance regulation cell behavior and 3D printing to build high-strength nano-composite hydrogel artificial bone tissue research.
study, the team constructed a multi-channel, temperature-molded 3D bio-preparation system (Bioscaffolder 3.1, GeSiM).
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alternating printing of two channels to achieve cell-containing "living" artificial bone tissue.
early stage, hyaluronic acid provides cell protection, maintaining high cell survival and precise scheduling.
the late support system controls the release of bone repair active ions (magnesium, silicon ions, etc.) to promote cell differentiation and functionalization.
further in vivo animal experiments confirmed that the "live" bone tissue, not only has excellent repair ability in the bone defect site, but also can achieve the formation of new bone ectopic.
therefore, the study will promote the application of 3D biomanufacturing technology in tissue repair regeneration.
research has been supported by the National Key Research and Development Program, Shenzhen Peacock Team, National Nature Fund, National High-Tech Research and Development Plan (863 Plan) Guangdong Province's top young talents and Shenzhen Science and Technology Commission.
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