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A new study suggests that a bacterium found in milk and beef can cause rheumatoid arthritis in some people who already have a genetic predisposition.
the bacteria may be a common cause of rheumatoid arthritis and Crohn's disease.
rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation, deformity and loss of function in the joints. Most of the patients in
are female.
estimates that the number of RA patients worldwide will exceed 8.5 million by 2023.
Crohn's disease is also an inflammatory disease.
201 out of every 100,000 Chinese adults suffer from Crohn's disease.
what do these two diseases have in common other than being characterized by inflammation? In fact, according to a new study recently published in Frontiers in Cell and Infectious Microbiology, the two have much in common.
both diseases have similar genetic backgrounds and are usually treated with similar immunosuppressants because they are autoimmune diseases.
the study's authors include UCF infectious disease expert Saleh Naser, rheumatologist Dr. Shazia B?g and UCF Medical School Doctoral student in biomedical research. "These two inflammatory diseases, which affect the intestines and joints, have the same genetic defects and use the same medication,"
Naser said.
but do they have common causes? That's the problem we're going to solve. "In past studies, Naser has found a link between the ostrichado subspecies (MAP) and Crohn's disease, and naturally raises questions about whether MAP is also associated with rheumatoid arthritis,"
.
in fact, Naser is currently participating in a clinical trial to see if Crohn's disease can be treated with antibiotics.
so if MAP is shown to be associated with rheumatoid arthritis, the disease also appears to be treated with antibiotics specifically for the bacteria.
genetic mutation plus MAP means higher risk researchers analyzed clinical samples from 100 patients with rheumatoid arthritis.
78 of them had the same genetic mutation as those with Crohn's disease: the PTPN2/22 gene.
40 percent of patients with rheumatoid arthritis with this genetic mutation also have MAPS. "We believe that people who are born with this genetic mutation have a very high risk of rheumatoid arthritis by drinking contaminated milk or eating infected beef and then being exposed to MAP," said
Naser. "We don't know the cause of rheumatoid arthritis, so we're glad we found this connection," said
." "We need to find out why there are more Maps in these patients because they have rheumatoid arthritis that causes MAP to appear, or is it because of the emergence of MAP, " said the authors of the
Future Study. If we find out why, we can start treatment for MAP bacteria. "To achieve this, the researchers plan to conduct further research in the hope that their findings will be reproduced,"
.
scientists say we should take national research to find out how many patients suffer from both rheumatoid arthritis and Crohn's disease. they also plan to study the correlations between people of different countries and ethnicities
.
Naser explains: "Knowing the role of MAP in rheumatoid arthritis means that the disease can be treated more effectively.
finally, we were able to use combination therapy for both inflammation and bacterial infections.
"