echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Microbiology News > A Computational Method to Search for DNA Structural Motifs in Functional Genomic Elements

    A Computational Method to Search for DNA Structural Motifs in Functional Genomic Elements

    • Last Update: 2021-02-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    The rapidly increasing availability of
    DNA
    sequence data from modern high-throughput experimental techniques has created the need for computational algorithms to aid in motif discovery in genomic DNA. Such algorithms are typically used to find a statistical representation of the nucleotide sequence of the target site of a DNA-binding protein within a collection of DNA sequences that are thought to contain segments to which the protein is bound. A major assumption of these algorithms is that the protein recognizes the primary order of nucleotides in the sequence. However, proteins can also recognize the three-dimensional shape and structure of DNA. To account for this, we developed a computational method to predict the local structural profiles of any set of DNA sequences and then to search within these profiles for common DNA structural motifs. Here we describe the details of this method and use it to find a DNA structural motif in the
    Saccharomyces cerevisiae
    yeast genome that is associated with binding of the transcription factor RLM1, a component of the protein kinase C-mediated MAP kinase pathway.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.