echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > A group of common viruses closely related to type 1 diabetes

    A group of common viruses closely related to type 1 diabetes

    • Last Update: 2022-10-01
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    A new study presented at the annual meeting of the European Association for the Study of Diabetes in Stockholm, Sweden (September 19-23) found that a common group of viruses is strongly associated
    with type 1 diabetes (T1D).

    The Australian analysis found that people who carry the T1D gene are 8 times more
    likely to be infected with enteroviruses than people without the T1D gene.

    T1D is one of the most common forms of diabetes in children, and its incidence has been rising
    globally in recent decades.

    Over time, high blood sugar levels can damage the heart, eyes, feet, and kidneys and shorten life expectancy

    Exactly what triggers an attack on the immune system is still debated, but it is thought to be related
    to a combination of genetic predisposition and one or more environmental triggers, such as a viral infection.

    Some of the strongest evidence of viral infection points to enteroviruses

    Vaccines that attempt to reduce the incidence of T1D by preventing enterovirus infections have entered clinical trials1, and confirmation of the role of enteroviruses will support this and other T1D primary prevention efforts

    To explore this link in greater depth, Sonia Isaacs of the Department of Pediatrics and Child Health at the University of New South Wales School of Clinical Medicine, Australia, and his colleagues conducted a systematic review and meta-analysis
    of existing research on the topic.

    The meta-analysis, the largest in the field, included data
    from 12,077 participants (aged 0-87 years) in 60 controlled observational studies on the PubMed and Embase databases.

    5981 participants had T1D or islet autoimmunity (usually progressing to T1D

    Enterovirus RNA or proteins are markers of current or recent infections and are detected
    in blood, feces, or tissue samples through a range of advanced and highly sensitive molecular techniques.

    People with islet autoimmunity are twice as likely to test positive for enteroviruses as
    people without islet autoimmunity.

    Patients with T1D are 8 times more
    likely to have enterovirus infection than patients without T1D.

    On top of that, patients with T1D are more than 16 times more likely to detect an enterovirus infection within a month of diagnosis of T1D than
    in patients without T1D.

    The researchers concluded that there is a clear association
    between enterovirus infection and islet autoimmunity and T1D.

    Ms Isaacs added: "These findings provide further support for ongoing work to develop vaccines to prevent the development of islet autoimmunity, thereby reducing the incidence
    of T1D.

    There are several theories
    about how enteroviruses increase the risk of developing T1D.
    For example, it is thought that their interaction with specific genes may be important

    Ms Isaacs explains: "Our study found that patients with T1D who were both at genetic risk and had a first-degree relative of T1D were 29 times more
    likely to be infected with enteroviruses than other patients.

    The number, time, and duration of enterovirus infection, and even the site of infection may also be important
    The "leaky gut" hypothesis holds that viruses originating in the gut may move to the pancreas with activated immune cells, where low levels of persistent infection and resulting inflammation can lead to an autoimmune response

    Viral infections are also thought to be linked to other factors, such as diet, imbalances in the gut microbiome, and possibly even chemical exposure
    in the womb (during pregnancy) or early childhood.
    There's still a lot to learn

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.