A large-scale aging-related gene expression spectrum database was built.

A large-scale database of aging-related gene expression has been built for four species, including humans, according to a study published Wednesday in the British journal Nature Communications.
a team of German scientists analyzing the data, found that the expression of age-related genes is consistent with the expression of the gene associated with degenerative chronic diseases, but not to cancer.
research on aging and aging-related diseases has always been a difficult problem in human medicine.
but with the determination of the "aging gene", the potential molecular mechanism of disease in the aging process is gradually being revealed, providing a new genetic basis for predicting aging-related diseases.
in this study, Christopher Caleta, a researcher at the University of Kiel in Germany, and colleagues produced a large database of age-related gene expression, derived from four species - four groups of humans, mice, zebrafish and mackerel at different ages.
team analyzed publicand lyusable data from patients with aging-related diseases.
found that gene expression patterns during aging moved closer to degenerative chronic diseases and deviated from those observed in cancer.
at the same time, they have found similar antagonistic relationships at the genomic level, where cancer and degenerative diseases have a large number of risk alleles, but these genes have the opposite effect on the tendency of both diseases.
, the team found that the main factors influencing the processes of aging-related diseases are associated with processes related to the immune system and cell division.
researchers concluded that the results reveal a "check and balance" between cancer and degenerative chronic diseases, helping to explain a previously observed phenomenon: that the leading cause of death in humans in late aging changes from cancer to degenerative chronic diseases.
more important, the discovery opens up new avenues for the treatment and prevention of ageing-related diseases in the future.
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