A lot of fat is found in the tumor!

A few days ago, the "Immune" magazine under the "Cell" publishing house published an important discovery about tumors: Scientists from the Salk Institute discovered that the tumor microenvironment is full of oxidized fat molecules

This discovery deepens our understanding of the tumor microenvironment

The researchers pointed out that a common metabolic change in the tumor microenvironment is the accumulation of lipids

In the past, people have been wondering why the killer T cells in the tumor always turn one eye and close the other to the surrounding cancer cells, indulging the growth of cancer cells

The reason why these T cells are greedy is that they express a protein called CD36 on their surface

"We found that when T cells'stress' under the action of oxidized fat, they shut down their anti-tumor function,

▲Schematic diagram of this research (picture source: reference [1])

Now that it is known that CD36 is the key to the intake of "bad fat" by T cells, researchers have also found a potential solution

Researchers even thought that if you increase the oxidized fat in tumor cells, it can also activate tumor cell death

Taken together, the researchers found in this paper that there are many fat molecules in the tumor microenvironment, especially oxidized fat

Note: The original text has been deleted

Reference materials:

[1] Shihao Xu, et al.

[2] “Bad fat” suppresses killer T cells from attacking cancer, Retrieved June 11, 2021, from https:// attacking-cancer/