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Polylactic acid ( PLA), also known as polylactide, is a type of aliphatic polyester polymerized with lactic acid as a monomer
.
Polyglycolic acid (PGA) is a synthetic polymer material with good biodegradability and biocompatibility.
Polylactic acid ( PLA), also known as polylactide, is a type of aliphatic polyester polymerized with lactic acid as a monomer
Compared with PLA, PGA has one less methyl group in the main chain unit, so it has better hydrophilicity and faster hydrolysis than PLA.
The copolymerization of PGA and PLA into poly(lactide-co-glycolide) (PLGA) can significantly improve PLA.
The degradation rate
.
The copolymerization of PGA and PLA into poly(lactide-co-glycolide) (PLGA) can significantly improve PLA.
The degradation rate
.
Compared with PLA, PGA has one less methyl group in the main chain unit, so it has better hydrophilicity and faster hydrolysis than PLA.
At present , the preparation of PLGA mostly adopts the ring-opening polymerization method
.
Common ring-opening polymerization is to separately dehydrate and cyclize glycolic acid and lactic acid to synthesize two monomers of glycolide (GA) and lactide (LA), and then ring-opening polymerization of GA and LA to obtain a PLGA random copolymer
At present , the preparation of PLGA mostly adopts the ring-opening polymerization method
The ratio of PGA and PLA in the PLGA copolymer is different, and the crystallinity is also different.
The crystallinity of the copolymer is different, and the water absorption rate is different
.
Lactic acid is less hydrophilic than glycolic acid, so PLGA copolymers rich in lactide are more hydrophilic than copolymers rich in glycolide
The ratio of PGA and PLA in the PLGA copolymer is different, and the crystallinity is also different.
In addition to its application as a conventional degradable plastic , PLGA is also widely used as a functional pharmaceutical excipient to control the release of parenteral drugs, as well as for the production of bioabsorbable implantable medical devices for orthopedics, cardiovascular and wound healing applications
.
.
,Of PLGA also widely used as a functional control of pharmaceutical excipients for parenteral drug delivery, and for the production for Biomechanics, cardiovascular and wound healing applications of resorbable implantable medical device
Recently, Dung Geng has launched a new PLGA functional polymer process technology, which integrates molecular structure control, lower processing temperature, control crystallization speed and improved polymer thermal stability advantages, which can significantly improve the overall performance of PLA and PGA
.
Recently, Dong Geng has launched a new PLGA functional polymer process technology, which integrates molecular structure control, lower processing temperature, control crystallization speed and improve polymer thermal stability This technology integrates the advantages of molecular structure control, lower processing temperature, control of crystallization speed, and improvement of polymer thermal stability.
This technology integrates molecular structure control, lower processing temperature, control of crystallization speed, and improvement of polymer thermal stability.
The combination of sexual advantages can significantly improve the overall performance of PLA and PGA
.
Can significantly improve the overall performance of PLA and PGA
Dong Geng has complete technical solutions for degradable materials ( PLA/PGA/PBS/PLGA/PPC/PCL), from chemical research and development to process package development, from key equipment manufacturing to pilot service, and the combination of different dimensions to create process solutions The optimal solution of the scheme
.
.
Dong Geng has complete technical solutions for degradable materials ( PLA/PGA/PBS/PLGA/PPC/PCL), from chemical research and development to process package development, from key equipment manufacturing to pilot service, and the combination of different dimensions to create process solutions The optimal solution of the scheme
.
Currently, commercialized projects include PLA and PBS, and PGA/PLGA/PXA are still in the pilot stage.
In addition, Dong Geng has also increased investment in the research and development of PPC and PCL processes and equipment to meet future industry development needs
.
In addition, Dong Geng has also increased investment in the research and development of PPC and PCL processes and equipment to meet future industry development needs
.
Currently, commercialized projects include PLA and PBS, and PGA/PLGA/PXA are still in the pilot stage.
In addition, Dong Geng has also increased investment in the research and development of PPC and PCL processes and equipment to meet future industry development needs
.
After years of continuous research and development and process optimization from the synthesis, purification and polymerization process of lactide, Tung Geng has reached the industry-leading level of process technology
.
The two PLA manufacturers' installations served by Dong Geng have been successfully put into production, providing high-quality products to the market steadily, and are rapidly advancing the construction of 300,000 tons of world-class PLA installations
.
.
The two PLA manufacturers' installations
served by Dong Geng have been successfully put into production, providing high-quality products to the market steadily, and are rapidly advancing the construction of 300,000 tons of world-class PLA installations .
After years of continuous research and development and process optimization from the synthesis, purification and polymerization process of lactide, Tung Geng has reached the industry-leading level of process technology
.
The two PLA manufacturers' installations served by Dong Geng have been successfully put into production, providing high-quality products to the market steadily, and are rapidly advancing the construction of 300,000 tons of world-class PLA installations
.
Taking PLA as the starting point, a complete series of polyalkylate degradable materials from PLA to PGA, PLGA, and PXA.
With a brand-new height and attitude, Dong Geng provides the best process technology and technology for the development of the industry from monomer to polymer.
Product solutions, promote the development of new bio-based green and degradable materials, and make outstanding contributions to the realization of green emission reduction
.
With a brand-new height and attitude, Dong Geng provides the best process technology and technology for the development of the industry from monomer to polymer.
Product solutions, promote the development of new bio-based green and degradable materials, and make outstanding contributions to the realization of green emission reduction
.
Taking PLA as the starting point, a complete series of polyalkylate degradable materials from PLA to PGA, PLGA, and PXA.
With a brand-new height and attitude, Dong Geng provides the best process technology and technology for the development of the industry from monomer to polymer.
Product solutions, promote the development of new bio-based green and degradable materials, and make outstanding contributions to the realization of green emission reduction
.
