Compared with ordinary wounds, diabetic wounds are often more susceptible to infection and difficult to heal
The research results were recently published in "Germany Applied Chemistry", and were selected as VIP papers and cover results, and were reported by the journal's official media
Associate Professor After the skin barrier of diabetic patients is damaged, the blood sugar at the wound site is high, which provides more nourishment for bacterial proliferation and makes the infection more serious
Based on the preliminary research foundation of the high stability modification of the DNA probe on the surface of platinum nanoparticles and the release of high fidelity signals, the research team developed a nanoenzyme activated by bacterial infection, which simultaneously broke the low local hydrogen ion concentration under physiological conditions.
The research team first synthesized a platinum nanozyme functionalized with an aptamer.
Schematic diagram of preparation route and activation of nanoenzyme capsule (APGH)
Schematic diagram of preparation route and activation of nanoenzyme capsule (APGH)
In the end, the research team selected diabetic wounds as the research model, and used APGH capsules to treat the wounds infected by Staphylococcus aureus SA as a control
APGH treated the wounds of diabetic mice to heal quickly
APGH treated the wounds of diabetic mice to heal quickly
pH and hydrogen peroxide limits
Related paper information: https://doi.
org/ 10.
1002/anie.
202107712 https://doi.
org/ 10.
1002/anie.
202107712
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
