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Allogene Therapeutics is a clinical-stage biotechnology company developing allogeneic chimeric antigen receptor T-cell (AlloCAR T) products targeting cancer
Allogene's TurboCAR platform specifically activates signaling of specific cytokines in CAR-T cells
▲Introduction to ALLO-605 (Image source: Allogene's official website)
Preclinical results from ALLO-605, presented at the American Society of Hematology (ASH) annual meeting in December 2020, show that TurboCAR technology may improve cell therapy colonization and persistence and delay T cell exhaustion
Rafael Amado, MD, executive vice president of research and development and chief medical officer at Allogene, said: "Orphan drug designation marks an important step toward developing an anti-BCMA portfolio for patients with multiple myeloma and providing patients with an allogeneic CAR-T product.
References:
Allogene Therapeutics Receives FDA Orphan-Drug Designation for ALLO-605, its First TurboCAR T Cell Product Candidate, for the Treatment of Multiple Myeloma.