A new microscope allows high-throughput 3D adaptive optics imaging

Microscopy is an important tool in biomedical research because it enables detailed observation and imaging of tissue

About a year ago, a research team led by Professor CHOI Wonshik from the Centre for Molecular Spectroscopy and Dynamics (CMSD) at the Institute for Basic Sciences (IBS) demonstrated an imaging technique called "reflection matrix microscopy" that combines hardware and the ability to compute advanced adaptive optics

Therefore, this technique becomes a suitable candidate for label-free, non-invasive high-resolution optical imaging inside biological tissues

While the performance of reflection matrix microscopy is amazing, it is not without its drawbacks

In new research published in the journal Light: Science and Applications, the IBS team recently unveiled a new and improved version of their previous AO microscopy technique

To speed up data acquisition, Choi's team used compressed sensing in the context of matrix imaging

In image post-processing, they employed a compressed "time-reversal matrix" and a unique algorithm to identify sample information and aberrations, respectively

Compressed time-reversal matrix imaging enables near real-time AO volumetric imaging

This will open a new avenue for the practical application of matrix imaging in various fields of wave engineering including biomedical imaging