A new strategy to promote functional recovery after stroke was found

The research team of Professor Zhao Bingxuan of Fudan University's National Key Laboratory of Medical Neurobiology and The Institute of Brain Sciences found that a drug called "recombinant ADAMTS13" can promote angiogenesic and functional remodeling after stroke, thus effectively improving neurological dysfunction caused by stroke. Recently, the results of the research were published online
Journal.
Zhao Bingxuan team used live mice cerebrovascular multi-photon microscope real-time dynamic imaging and other advanced technology, found that after knocking out the ADAMTS13 gene, mice in the stroke recovery period of the blood-brain barrier damage is more serious, the blood vessels of macromolecule substances leakage more, resulting in a decrease in the coverage of hemangiocytes and smooth muscle cells, resulting in cerebrovascular fine blood vessels, perfusion of blood vessels reduced, indicating that ADAMTS13 is the key to the reshaped blood vessels.
on the basis of knocking out the ADAMTS13 gene, the researchers removed another gene, VWF, and found that the blood-brain barrier damage and leakage in the mice were significantly reduced. Through virus and drug intervention, it is further proved that the mechanism of action of ADAMTS13 is Gal-3 and An-2 in Weibel-Palade small bodies acting on microvascular endothroid cells through VWF, which in turn causes the vein endostrophic cell growth factor VEGF subject 2 phosphate.
At the same time, the researchers used the drug "recombinant ADAMTS13" to increase ADAMTS13 levels in mice, and found that the mice did develop more and more mature capillaries in their brains, and that the mice's sensation and motor function improved significantly.
study confirms for the first time that ADAMTS13 is an important molecule for regulating angiogenesic, mature and functional remodeling after stroke. Better understanding and targeted treatment of angiogenesic and functional remodeling will help restore impaired nerve function in stroke patients. (Source: Huang Xin, China Science Daily)