A new type of skull fixation system based on natural silk protein.

Skull fixation products are used for the fixation and repair of the skull in neurosurgery craniofacial repair, and play a role in the protection of the skull.
research on biocompatibility, good mechanical properties, human biodegradable absorption of skull fixed materials and medical products has been a hot research topic in the field of new materials.
recently, the Team of Tao Hu Researchers of the Shanghai Institute of Microsystems and Information Technology of the Chinese Academy of Sciences and Mao Ying, Professor of Huashan Hospital affiliated with Fudan University, have made progress in the field of silk protein skull fixation systems. On January 26,
, the research was published online at Advanced Healthcare Materials under the title A Silk HealthSystem System for Curry.
the study, a new type of skull fixation system based on natural silk protein (including silk protein bone nails and connecting tablets) showed good biocompatibility and excellent skull fixation and reconnection in 12 months of preclinical canine experiments.
by optimizing the silk protein extraction and remolding process, the preparation of large-size, uniform material silk protein block material.
on this basis, the internal mechanism of "protein molecular structure-mechanics/degradation property regulation" is studied, and the mechanical strength and degradation rate of silk protein material are adjusted by controlling the molecular weight and recrystallization level of silk protein. Another great advantage of
silk protein is that it stabilizes and releases bioactive ingredients, so silk protein bone nails and connecting tablets release bioactive drugs to prevent infection, enhance bone regeneration and provide other treatments to promote healing.
, the results show that silk protein material seisopher material sexist and gamma-ray sterilization, nuclear magnetic resonance imaging, X-ray medical testing and other existing medical methods have perfect compatibility.
this craniofacial fixation system based on natural bioproteins compensates for the defects of existing metal, bioceramic and chemically synthesized polymer materials, which is the future development direction of human implanted medical materials, with great market potential and practical clinical application value.
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