A new type of sugar-lowering active ingredient has been found in Chinese herbal fruits

Science and Technology Daily Kunming, November 8 (Reporter Zhao Hanbin) reporter 8 from China
Kunming Plant Research Institute was informed that the research and development team of the institute's new natural medicine found that Chinese herbal fruits have a new type of sugar-lowering active ingredients, not only for the discovery of new blood sugar-lowering pilot molecules to provide chemical and pharmacological basis, but also to broaden the new use of herbal fruits to provide an important scientific basis.
" diabetes clinical treatment drugs mainly include insulin and oral anti-sugar drugs, however, due to the risk of hypoglycemia and various side effects, it is urgent to develop a variety of structure, the role of different targets of new blood sugar-lowering drugs. Chen Jijun,
Institute of Plant Research in Kunming, China, said.
grass fruit is the dried ripe fruit of the perennarial herb herb fruit, is a well-known traditional Chinese medicine and traditional spices, the medicine has the effect of dry and humid temperature, intercept malaria and sputum and so on. In the exploration of natural source anti-diabetic drugs, Chen Jijun's research team found for the first time that grass fruit extract significantly reduced fasting and random blood sugar in mice, and had no significant effect on the amount of food and weight in mice.
study group, guided by active screening and liquid chromatography mass spectrometry analysis, carried out research on the active ingredients of oxalicose hypoglycemia and found 2,6-epoxy II from the active site around targets closely related to diabetes α-glucosinase, protein tyrosine phosphatase 1B, etc. There are 115 compounds with 5 types of structures, such as aromatic octane, chained ddifangoquine, flavanol-fatty alcohol hybrid, flavanol-monoxyl heterocyte, and flavanol glycol glycogen, of which 66 are new compounds, which enrich the chemical composition of grass fruit.
they also found that the grass fruit contained 78 compounds to α-glucoside enzyme inhibitive activity, 18 compounds to the protein tyrosine phosphatase 1B inhibition activity. The novel structure of flavanol-fatty alcohol, monoamide hybrid is the diabetes target double inhibitor.
series of research results have been published in the field of natural drug research and development, "plant chemistry" "bio-organic chemistry" and other five well-known international journals.