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    Home > Active Ingredient News > Infection > A&R: B-cell reconstitution strongly associated with COVID-19 vaccine responsiveness in rheumatic patients receiving rituximab

    A&R: B-cell reconstitution strongly associated with COVID-19 vaccine responsiveness in rheumatic patients receiving rituximab

    • Last Update: 2022-08-11
    • Source: Internet
    • Author: User
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    OBJECTIVE: To assess the association between detectable antibody responses to COVID-19 vaccination and factors such as B -cell depletion in patients receiving rituximab (RTX.


    OBJECTIVE: To assess the association between detectable antibody responses to COVID-19 COVID-19 vaccination and factors such as B -cell depletion in patients receiving rituximab (RTX) therap.


    Methods: We performed a retrospective review of cases of adult patients who received RTX and completed SARS-CoV-2 messenger RNA vaccinati.


    RESULTS: Among the 56 patients treated with RTX , a significant difference in the level of B cell reconstitution was observed in seropositive patients compared with vaccinated seronegative patients (the proportion of B cells in total lymphocyte.


    Conclusions: B -cell reconstitution and longer time since the patient's last exposure to RTX were associated with positive serological responses to the COVID-19 vaccin.


    Source: Jinich,.


    Jinich,.
    , Schultz,.
    , Jannat-Khah,.
    and Spiera,.
    (2022), B Cell Reconstitution Is Strongly Associated With COVID-19 Vaccine Responsiveness in Rheumatic Disease Patients Who Received Treatment With Rituxim.
    Arthritis Rheumatol, 74: 776-78https://d.
    org/11002/a.
    42034 https://d.
    org/11002/a.
    42034Comment here
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