A remedial synthesis pathway for radon nucleotides.

. The namemost cells in the process of updating their
nucleic acids
(especially RNA), to break down nucleic acids to produce nucleosides and free bases. The process by which cells re-synthesize
nucleotides
free bases or nucleotides is called remedial synthesis. Unlike synthesization from the beginning, remediation synthesis is simpler and consumes less energy. Two enzymes with different specificity are involved in the remediation synthesis of nicoside nucleotides. Adenine phosphate ribosomyl
transmostic enzyme
(Adenine phosphoribosyl transterase, APRT) catalytic PRPP and adenine synthesis AMP:the body's remedial synthesis of adenosine nucleosides can only be catalyzed by adenosine
kinase
, so that adenine nucleotides produce adenine nucleotides.remediation synthesis of nicoside nucleotides is a secondary approach. Its physiological significance lies in saving energy and reducing the consumption
amino acids
the body. On the other hand,
tissues
, such as human white blood cells and plateplates, brain, bone marrow, spleen, etc., which lack the main synthesis pathway, have important physiological significance. Seseh Nyhan syndrome, for example, is caused by a serious genetic defect in HGPRT. The disease is a sexual chain genetic defect found in men. The patients showed increased uric acid and neurological abnormalities. Such as brain dysplia, low intelligence, aggressive and destructive behavior, often bite their lips, hands and toes, so also known as self-destructing appearance. Its uric acid increase is easier to explain, due to the lack of HGPRT, so that the decomposition of THEP can not be used and accumulation, PRPP promotes the synthesis of radon from the beginning, so that the decomposition product - uric acid increase. The mechanism of neurological symptoms is not clear.
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