A review of the progress of the study on the interaction between organic and inorganic nanoparticles and ABC transport proteins.

ATP Binding Cassette Transporters is a superfamily transporter protein located on the tumor cell membrane that can be fed through ATP hydrolysis and pump anti-tumor drugs out of the body at reverse concentrations.
this phenomenon is called multidrug resistance mechanism, greatly increasing the difficulty of tumor treatment.
in recent years, researchers have built a series of drug vectors based on nanoparticles that they believe can accumulate specifically in tumor cells by osmoticing and retention effects, EPR.
at the same time, because they are swallowed in the form of more than one intracellular, avoiding the extritoral action of ABC transport protein, it can be better used in tumor markers and treatment related research.
however, the widely reported cytotoxicity of nanoparticles makes its application impossible and poses a potential threat to the environment and human health.
, the researchers studied the toxicity mechanism of nanoparticles and found that the toxicity was also associated with the activity of ABC transport proteins on the cell membrane.
plus ABC transporter protein on nanoparticle excretion also affectits its effect in tumor treatment and markers, so it is necessary to systematically study the interaction between ABC transporter protein and nanoparticles, and provide reference for the synthesis and application optimization of nanoparticle drug vectors.
mechanism for organic and inorganic nanoparticles to interact with ABC transportproteins.
, the surface of organic nanoparticles contains aerosols and other accessories, which can be inhibited by changing membrane fluidity, removing ATP and closed substrate binding sites.
inorganic nanoparticles act as transport protein substrates, competitively inhibiting their function.
, Dr. Yin Jian, of the Suzhou Institute of Biomedical Engineering technology of the Chinese Academy of Sciences, was invited by Current-Jian chemistry to write a review paper on the interaction between nanoparticles and ABC transport proteins, summarized the progress of the research on ABC transport proteins and their inhibitors, systematically expounded the progress of the interaction between organic and inorganic nanoparticles and ABC transport proteins, and looked forward to the guiding role of this interaction in the study of new nanoparticle synthesis.
the author, through the literature summary, found that organic nanoparticles can achieve the organic inhibition of ABC transport protein by adding surface accessories, including surfactants, polymers, polysaccharides and lipids.
and inorganic nanoparticles are more used as transport protein substrates, competitively inhibiting their function.
the review emphasizes that although the interaction between ABC transport protein and nanoparticles has been widely reported, it is a single phenomenon, and has not been systematically proved, and the regulatory mechanism in its process has not been clear.
, therefore, the future research focus in this field will be to demonstrate the full range of this interaction, and based on this to optimize and improve nanoparticles to promote the promotion and application of nanopharmaceuticals in clinical medicine.
research work has been supported by the National Natural Science Foundation of China, The Natural Science Foundation of Jiangsu Province, Jiangsu Province, the forward-looking research project.
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